These telomeric protein complexes in turn interact with diverse pathways to form the telomere interactome13 for telomere maintenance. However, the mechanisms by which the POT1-containing telosome communicates with telomerase to regulate telomeres remain to be elucidated. Here we demonstrate that TPP1 ...
Mammalian shelterin proteins POT1 and TPP1 form a stable heterodimer that protects chromosome ends and regulates telomerase-mediated telomere extension. However, how POT1 interacts with TPP1 remains unknown. Here we present the crystal structure of the C-terminal portion of human POT1 (POT1C) com...
Second, in both POT1 and TEBPa, short strand b10 after the kink is followed by another short strand b20 on the opposite side of b2; the three strands together form a protruding arm of the b barrel (Fig. 2b,c). Third, in addition to OB3 folds themselves, both POT1OB3 and TEBPaO...