Complete answer:TPP is the full form of the thiamine pyrophosphate. It is also known as thiamine diphosphate. It is a derivative of thiamine or vitamin B1. It helps in the metabolism of the carbohydrate and amino acids by stabilizing the acyl carbanion bio synthons. It ...
结果:TPP1是泛素化的,是去泛素化酶USP7的底物。 结论:TPP1泛素化不影响其已知的蛋白质相互作用,但导致蛋白酶体依赖的降解。 意义:这些发现确定了影响TPP1稳定性和功能的新通路。 摘要 端粒shelterin组分TPP1在端粒蛋白复合物组装和端粒酶募集和调节中具有关键功能。在这里我们确定USP7是TPP1寡核苷酸/寡糖结合折叠的...
Download: Download full-size image FIGURE 2.. TIN2 binding required for TPP1 and POT1b to localize to telomeres. A, telomeric DNA ChIP for FLAG-HA2 TIN2 alleles (anti-HA) and MYC-TPP1 (anti-MYC) in TIN2F/F MEFs with or without Cre treatment (72 h). PI, preimmune. B, quantific...