[3]Zhang Y, Li S, Lyu Z, et al. The co-mutation of EGFR and tumor-related genes leads to a worse prognosis and a higher level of tumor mutational burden in Chinese non-small cell lung cancer patients[J]. Journal of Thoracic Disease, 2022, 14(1): 185-193. DOI: 10.21037/jtd-21...
当TP53正常(野生型)时,p53通常表达为部分阳性(写作:弱阳、斑驳+、部分+、10%-60%或<=2+); TP53(或p53)被认为是区分高级别浆液性卵巢癌(后简称高浆)与低级别浆液性卵巢癌(后简称低浆)的标记物之一;高浆通常具有TP53突变。 与其他癌种不同,高浆与低浆并不是同一类型肿瘤的两种分化形式,而是两种不同起源...
[3]Zhang Y, Li S, Lyu Z, et al. The co-mutation of EGFR and tumor-related genes leads to a worse prognosis and a higher level of tumor mutational burden in Chinese non-small cell lung cancer patients[J]. Journal of Thoracic Disea...
10. Canale M, Petracci E, Delmonte A, et al.Concomitant TP53 Mutation Confers Worse Prognosis in EGFR-Mutated Non-Small Cell Lung Cancer Patients Treated with TKIs[J]. J Clin Med, 2020, 9 (4). 11. Yang L, Zhou...
Missense mutations (75.6%; G:C > A:T [48.31%]) were the predominant mutation type, occurring within the DNA-binding domain (DBD; 92.41%) and concentrated in exons 5-8 (82.05%). The extent of the impact on prognosis was dependent on the location of the mutations. G245/R273 mutations...
基于此,天津医科大学肿瘤医院张会来教授团队展开研究,近期在Am J Hematol(IF=10.047)杂志上发表了题为“Comprehensive analysis of TP53 mutation characteristics and identification of patients with inferior prognosis and enhanced immune ...
在此基础上,该合作团队于近日在Advanced Science杂志上发表题为“MGAT4A/Galectin9-drivenN-glycosylation aberration as a promoting mechanism for poor prognosis of endometrial cancer withTP53mutation”的合作研究。该研究报道了基于糖基化相关基因的子宫内膜癌新型分子分型系统,阐明了过量表达的α-1,3-甘露糖基糖...
7. Chen F, Gu Q, Hu C, Cai X, Lei S. Poor prognosis of pulmonary sarcomatoid carcinoma with KRAS mutation and ALK fusion. Onco Targets Ther. 2019;12:3321-3325. doi: 10.2147/OTT.S196751 8. Li X, He Y, Zhu J...
[9] Bowen D, Groves MJ, Burnett AK, et al. TP53 gene mutation is frequent in patients with acute myeloid leukemia and complex karyotype, and is associated with very poor prognosis. Leukemia. 2009. 23(1): 203-6. [10] Kulasekararaj AG,...
alandtimetoCRPC.TP53 mutationwasanindependentriskfactoraffectingtimetoCRPC.Conclusion:Inpros- tatecancer,TP53 mutation wassignificantlyassociated withearlyageatdiagnosis,poorpathologicalfeatures, andworseprognosis.Inaddition,TP53 mutationwasanindependentriskfactoraffectingthetimetoCRPC.Pro- spective,multi-centerand...