This study reports the following: (1) frequency of TP53 comutation within each component of the European LeukemiaNet 2022 acute myeloid leukemia risk classification, (2) relevance of TP53 mutated variant allelic fraction <10%, (3) prognostic impact of -7,-5/del(5q),-17/abn(17p), complex...
结论伴TP53基因异常AML患者中错义突变常见,突变位点主要分布于DNA结合结构域。TP53基因异常与高龄、复杂核型相关,且常与多个基因突变相伴出现。以地西他滨为基础的诱导化疗及异基因造血干细胞移植可能会提高患者生存率。关键词: 白血病,髓样,急性;基因,TP53;复杂核型;预后 ...
Low-frequency TP53 hotspot mutation contributes to chemoresistance through clonal expansion in acute myeloid leukemiaTP53 mutations (TP53mut) in AML patients associate with poor prognosis that may affect therapy and outcome. In addition to TP53 mut patients, TCGA AML patient sequencing data show that ...
The high expression of the p53 protein, not the TP53 mutation, is predictive of poor survival in patients with ESCC, and p53 protein expression might have the potential to be a prognosis biomarker and therapy target in ESCC.(责任编辑:佳学基因) ...
The prognostic impact of TP53 mutations has been demonstrated in CLL, AML, and MDS. However, data on the frequency and prognostic impact of TP53 mutations in ALL is scarce. Aims We aimed at determining the TP53 mutation frequency, the association with cytogenetic subgroups and age, as well as...
Tatsuya Masuda, et al., Impact of TP53 co-mutation on clinicopathological features, prognosis, recurrence patterns, and the efficacy of EGFR-TKI treatment after recurrence in resected early-stage EGFR-mutated lung adenocarcinoma, Clinical Lung Cancer (2025)....
Tatsuya Masuda, et al., Impact of TP53 co-mutation on clinicopathological features, prognosis, recurrence patterns, and the efficacy of EGFR-TKI treatment after recurrence in resected early-stage EGFR-mutated lung adenocarcinoma, Clinical Lung Cancer (2025)....
As ‘stemness scores’ have previously been applied to determine prognosis in AML31, we next asked whether a single-cell definedTP53multihit LSC signature might identify AML patients with adverse outcomes. Single-cell multi-omics allowed us to derive a 44-gene ‘p53LSC-signature’ (Supplementary...
急性髓系白血病(acute myeloid leukemia, AML)中,TP53基因异常与复杂核型(complex karyotype,CK)高度相关,70%的CK-AML存在TP53基因异常(突变和缺失分别占60%和40%),且TP53基因突变与老年、基因组复杂性、特定DNA拷贝数变异、单体核型以及不良预后相关。至少2/3...
Here we demonstrate that the presence of TP53 mutation has an independent impact on prognosis that is as great as having severe anemia and greater than having a bone marrow blast proportion of 10–29%. The muted impact of increased blast proportion and the absence of severe thrombocytopenia as ...