2023 年 9 月 9 日-12 日,2023 世界肺癌大会(WCLC)在新加坡盛大召开。在大会的口头报告专场,来自南方医科大学南方医院的蔡晓庭博士带来了题为「Surfaceome of TP53-Mutant NSCLC Reveals a Distinct Subtype with Immunotherapy Vulnerability, Characterized...
[7] 陈羽中, 沈波. EGFR敏感突变晚期非小细胞肺癌的靶向治疗进展 [J]. 临床肿瘤学杂志, 2019, 24(5): 9.[8] HONG S, GAO F, FU S, et al. Concomitant Genetic Alterations With Response to Treatment and Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Patients With EGFR-Mutant Advan...
近日,研究人员在EMBO Molecular Medicine上发表研究成果,揭示TP53-mutant AML抵抗CAR-T治疗的潜在机制,为增强CAR-T治疗TP53-mutant AML效果提供了新的见解。 研究人员发现CAR-T细胞治疗TP53-mutant AML作用时间延长,细胞衰竭标志物表达上调...
相关研究结果发表在Nature Genetics上,文章题为“Single-cell multi-omics identifies chronic inflammation as a driver of TP53-mutant leukemic evolution”。 TP53白血病转化中的趋同克隆进化 为了描述TP53-sAML的遗传图谱,研究人员通过批量靶向NGS和单核苷酸多态性(SNP)阵列分析了33名TP53-sAML患者。在28名患者中检测...
[12]Zhao Y, Pan Y, Cheng C, et al. EGFR-mutant lung adenocarcinoma harboring co-mutational tumor suppressor genes predicts poor prognosis. J Cancer Res Clin Oncol. 2020 Jul;146(7):1781-1789. DOI: 10.1007/s00432-020-03237-3 [13]Canale M, Petracci E, Delmonte A, et al. Impact of...
16 Miller,J. J. et al. Bifunctional ligand design for modulating mutant p53 aggregationin cancer. Chem. Sci. 10, 10802-10814, doi:10.1039/c9sc04151f (2019). 编辑︱杨彬薇 本文完 http://weixin.qq.com/r/KRDC2tLEgI--rZa590U7 (二维码自动识别)...
Single-cell, multi-omic characterization of hematopoietic stem and progenitor cells now shows the role of inflammation in transformation driven by mutations inTP53, with effects on the mutant clone but also non-mutant counterparts.doi:10.1038/s41588-023-01479-8Adam Benabid...
(n = 329TP53WT;n = 31TP53mutant).g,CEBPA(top) andGATA1(bottom) expression in the same cells as inaandb.h,CEBPAandGATA1expression ratio in the same patient cohort as ineandf.i,j, Proportion of immature erythroid (CD235a+CD71+) and myeloid (CD14+, CD15+or CD11b+) cells ...
1.野生型：如果TP53基因没有发生任何突变，即野生型（wild type），通常意味着该基因功能正常，细胞能够正常执行DNA修复和细胞周期控制的任务，相对低风险患癌。2.突变型：如果TP53基因发生突变，即突变型（mutanttype），可能导致基因功能异常，无法正常抑制细胞的恶性增殖以及DNA损伤的修复，增加了患癌风险。-基因突变...