Wnt成人肝脏基因突变免疫组化研究肝脏恶性肿瘤β-连环蛋白等位基因失衡序列特异性Background/Aims: Hepatic undifferentiated (embryonal) sarcoma (HUS) is an exc eptional hepatic malignant tumor in adults. Genetic studies were never reported in adult cases. Methods: In this study concerning three cases of ...
The mutually exclusive relationship between alterations in TP53 and Wnt/CTNNB1 further molecularly characterizes subsets of prostate cancers. Moreover, the alteration of KMT2C was more likely to co-occur with TP53 alteration, indicating a more aggressive phenotype of PCa, which was associated with ...
在实体瘤中,CEBPA变异最常见于肺腺癌,主要包括突变,然后是扩增、错义、移码、插入和缺失。在细胞培养中,当CEBPA转录因子功能完全并过表达时,CEBPA转录因子通过抑制上皮-间充质转化和Wnt/β-连环蛋白通路来抑制肺腺癌的迁移和侵袭。在TP53突变的肺腺癌中CEBPA的频繁缺失可能为这些肿瘤的侵袭性临床行为和相关的不良预后...
TheTP53gene is one of the most commonly mutated genes in cancers, and its encoded protein, p53, is a DNA damage response regulator. Thereby, overcoming p53-induced cell-cycle arrest and cell death is one of the hallmarks of tumorigenesis. However, tumor suppressor p53 regulates autophagy with ...
Improved prediction of prognosis and therapy response for lung adenocarcinoma after identification of DNA-directed RNA polymerase-associated lncRNAs Jiaao Yu Liqiang Lan Xiao Zhu Journal of Cancer Research and Clinical Oncology (2023) Sestrin2 reduces cancer stemness via Wnt/β-catenin signaling in ...
在细胞培养中,当CEBPA转录因子功能完全并过表达时,CEBPA转录因子通过抑制上皮-间充质转化和Wnt/β-连环蛋白通路来抑制肺腺癌的迁移和侵袭。在TP53突变的肺腺癌中CEBPA的频繁缺失可能为这些肿瘤的侵袭性临床行为和相关的不良预后提供了一个重要的机制。 本研究中大多数肺腺癌存在TP53错义突变,对标本的主要影响多为功能...
在细胞培养中,当CEBPA转录因子功能完全并过表达时,CEBPA转录因子通过抑制上皮-间充质转化和Wnt/β-连环蛋白通路来抑制肺腺癌的迁移和侵袭。在TP53突变的肺腺癌中CEBPA的频繁缺失可能为这些肿瘤的侵袭性临床行为和相关的不良预后提供了一个重要的机制。 本研究中大多数肺腺癌存在TP53错义突变,对标本的主要影响多为功能...
· 临床泌尿外科杂志 第 37 卷 态可用于探索前列 腺癌潜在治疗 方案的重要指标 .[13-15] 在本研究 中,TP53 突变型患者有更差的 总体生存和 CRPC-free生存,且 TP53 突变是影响 CRPC-free生 存的独立危险因素.Liu 等[9]认为 TP53和 Wnt/CTNNB1改变之间存在 的相互排斥 关系可进一步在分子生物学上表征...
同时, TP53 相关通路的突变情况也有很多特性,包括与SPOP的排他性,与Wnt/CTNNB1的排他性,以及常见的KMT2C共突变[5]。文献报道,具有KMT2C突变的患者对聚腺苷二磷酸核糖聚合酶抑制剂更为敏感,这也是一个潜在的治疗切入点[11]。期待后续对 TP53 突变相关共突变与前列腺癌临床特征、PARP抑制剂等新药疗效的关系进行...
Taken together, our data demonstrate that EZH2 promotes cell proliferation and tumor formation in cervical cancer through activating the Wnt/β-catenin pathway by epigenetic silencing via GSK-3β and TP53. 展开 关键词: EZH2 cervical cancer proliferation Wnt/β-catenin signaling GSK3β and TP53 ...