The p53 protein (also called TP53) was discovered as a protein bound to the SV40 large T antigen in transformed cells (reviewed in Levineet al.1and Lane and Benchimol2). Inadvertently, some of the first experiments in which p53 was overexpressed in cell lines used constructs encoding cancer-...
He and others encouraged Cheng to look into p53, a protein that regulates the cell cycle and functions as atumor suppressorthat was recently discovered to help elephants avoid cancer. Elephants have increased copies of the TP53 gene, which encodes the p53 protein, and Cheng decided to see wheth...
Just how does cII selection work in the Muta Mouse? Written in the context of lambda recombinant genetics, this paper explores the question further. 展开 关键词: lytic lysogeny lambda bacteriophage mutagenesis mechanism DOI: 10.1002/em.1035 被引量: 17 年份: 2001 ...
ROS-induced damage to DNA and DNA repair enzymes can induce genomic instability, and mutation of nuclear encoded genes such as TP53 promotes carcinogenesis (Colotta et al., 2009, Hussain et al., 2003). Mutation of mtDNA can also increase ROS production and promote cancer progression, as ...
ap53 may therefore serve as useful molecular biological markers for determining prognosis and treatment strategies in patients with noninvasive transitional cell carcinomas. This finding is potentially even more significant, because TP53 mutations can be analyzed in urine cells by noninvasive methods (347...
suppressor potential of PUMA, as was suggested by the fact that its loss accelerated MYC-induced lymphomagenesis.53,74Unexpectedly, PUMA deficiency protected mice efficiently from thymic lymphoma. Why does deletion of PUMA abrogate lymphoma formation whereas loss of its activator, TP53, does the ...
This work delves into the influence of cancer related mutations on the oligomeric state of p53 TD. Although different groups focused on this topic previously, they worked with different lengths of the peptides, some of them obtained by chemical synthesis and others by expression inE. coli, and ...
p53 immunohistochemistry reliably identifies samples with TP53 mutation in ovarian and endometrial cancers [83,84]. The most common abnormal p53 pattern is overexpression (68%), followed by null type (9%) and cytoplasmic (2%) patterns [85]. Regardless of histological subtype, HER2 amplification ...
p53 immunohistochemistry reliably identifies samples with TP53 mutation in ovarian and endometrial cancers [83,84]. The most common abnormal p53 pattern is overexpression (68%), followed by null type (9%) and cytoplasmic (2%) patterns [85]. Regardless of histological subtype, HER2 amplification ...
Overexpression of TP53 increased Pol η mRNA levels and enhanced luciferase activity in a reporter assay. Importantly, overexpression of a mutant TP53 (R175H) was unable to enhance luciferase expression. Unpublished data from our laboratory and other studies have confirmed higher expression levels of ...