PFS improvement was observed regardless of microsatellite instability status; in the TP53wt/MSS(pMMR) subgroup, the mPFS was not reached with selinexor vs 4.9 months with placebo. In patients with TP53wt, the most common adverse events (AEs) were nausea, vomiting, and diarrhea; most common ...
A significant increase in TP53 mutations on the transcribed strand was detected in Xpa-Null HUFs compared to Xpa-WT HUFs, but the TP53-mutant frequency overall was not significantly different between the two genotypes. BPDE induced mutations primarily at G:C base pairs, with approximately half ...
in TP53 mutations on the transcribed strand was detected in Xpa-Null HUFs compared to Xpa-WT HUFs, but the TP53-mutant frequency overall was not significantly different between the two genotypes. BPDE induced mutations primarily at G:C base pairs, with approximately half occurring at CpG si...
TP53截短队列患者的中位OS为1181天,而TP53野生型队列(TP53wt)和其他队列的中位OS分别为1474天和1486天(HRTP53truncating=1.61,95%CI:1.22~2.12,p=0.001,图3A)。抗癌管家-康爱管家,我们一起抗癌,治愈癌症不是梦。2年后,大约40%的TP53截短突变患者会发生死亡,而其他两组中约有25%患者发生死亡。此外,与TP53wt...
骨髓增生异常综合征(MDS)是起源于造血干细胞的一组异质性髓系克隆性疾病,其特征是外周血细胞减少和由高风险向急性髓性细胞白血病(AML)转化.TP53是一种抑癌基因,位于17p13染色体区域,包含11个外显子,其编码的p53蛋白有5个功能结构域.该蛋白通过DNA损伤修复,细胞周期调控,诱导凋亡等多种途径发挥着重要的肿瘤抑制作...
余盼目前担任河南小时代游乐设备有限公司法定代表人,同时担任河南小时代游乐设备有限公司执行董事兼总经理;二、余盼投资情况:余盼目前是河南小时代游乐设备有限公司直接控股股东,持股比例为99%;目前余盼投资河南小时代游乐设备有限公司最终收益股份为99%;三、余盼的商业合作伙伴:基于公开数据展示,余盼与夏珂、万李楠为商业...
经过长期随访,截至2024年4月1日,我们发现接受塞利尼索Selinexor治疗的TP53wt患者与接受安慰剂的患者相比,中位PFS(mPFS)存在显著差异。具体来说,塞利尼索Selinexor治疗组的mPFS为28.4个月,而安慰剂组仅为5.2个月(在36.8个月的随访期内,风险比HR为0.44;95%置信区间CI为0.27-0.73)。值得注意的是,无论MMR状态如何,塞...
2100: HMGB2 KD shortens G2/M, reduces cell, proliferation, and radio-sensitizes TP53wt and mutant GBM cellsdoi:10.1016/S0167-8140(24)02372-7Aline P. BeckerValesio BeckerEbin SebastianS. Jaharul HaqueJoseph McElroyAmy WebbJessica Fleming...
TP53 was previously thought to be a difficult target as it is often mutated, deleted or inactivated on both chromosomes in certain cancers. In the following study, the effects of restoration of wild-type (WT) TP53 activity on the sensitivities of MIA-PaCa-2 pancreatic cancer cells to the ...
Restoration of p53 pathways by Nutlin-3a in TP53Wt/MDM2Ampl cells.Jane MuretMeriem HasmimIzabela StasikAbdelali JalilAude MallavialleArash NanbakhshLudovic LacroixKaty BillotVéronique BaudJerome Thiery