Daston, George P.McNamee, PaulineNational Institute of Environmental Health SciencesEnvironmental Health PerspectivesDaston, G., and P. McNamee. 2005. Alternatives to toxicity testing in animals: Challenges and opportunities. Environ. Health Perspect. 113: 6....
An in-vitro toxicity testing - a reliable alternative to toxicity testing by reduction, replacement and refinement of animals. Int J of Adv in Pharmaceutical Sciences. 2010; 1: 15-31.M. Bhanushali, V. Bagale, A. Shirode, Y. Joshi, V. Kadam, An in-vitro toxicity testing: a reliable ...
Toxicity testing in laboratory animals provides much of the information used by EPA to assess the hazards and risks associated with exposure to environmental agents. The number of regulations, initiatives, and directives that require toxicity testing is growing. Therefore, EPA recognized the need for ...
It is predicted by experts that the number of animals used for toxicity testing in Europe will quintuple due to a plan to have a large variety of chemical tested. A. Y B. N C. NG 相关知识点: 试题来源: 解析 A 正确答案:A解析:此题是细节题,根据题目中的Europe定位在第一部分的第三段,...
Consensus report on the future of animal-free systemic toxicity testing Since March 2013, animal use for cosmetics testing for the European market has been banned. This requires a renewed view on risk assessment in this field. ... F Busquet - 《Altex》 被引量: 132发表: 2014年 An ...
Human subjects have been harmed in the clinical testing of drugs that were deemed safe by animal studies. Increasingly, investigators are questioning the scientific merit of animal research. This review discusses issues in using animals to predict human toxicity in pharmaceutical development. Part 1 ...
Regulatory authorities require toxicity testing on animals as part of the safety assessment for new drugs, chemicals, biologics, food additives, and medical devices. For new compounds or other chemical entities, organ weight changes are accepted as a sensitive indicator of chemically-induced effects on...
For studies of 2 to 6 weeks in duration in nonrodent species, testing is also recommended within 7 days of initiation of dosing, unless it compromises the health of the animals. If a study contains recovery groups, clinical pathology testing at study termination is recommended. The core ...
Similarly, preclinical toxicity testing is invariably done in young animals. However, the main brunt of adverse drug reactions is borne by the elderly age group. Also many determinants of drug response - pathophysiology, pharmacokinetics and pharmacodynamics are different in the elderly. It is ...
Levy JH, Brister NW, Shearin A et al (1989) Wheal and flare responses to opioids in humans. Anesthesiology 70:756–760 Article CAS PubMed Google Scholar Li PH, Ue KL, Wagner A et al (2017) Opioid hypersensitivity: Predictors of allergy and role of drug provocation testing. J Allergy ...