Allergenic Potential in Guinea Pigs (Magnusson-Kligman Maximisation Test).*TOXICOLOGYCuthbert, J. AInveresk Research International Ltd.D'Arcy-Burt, K. JCarr, S. MCuthbert JA, D'Arcy-Burt KJ, Carr SMA (1985) HMX: acute toxicity tests in laboratory animals. Report AD-A171598. US Army ...
In this study, male albino wistar rats (18) were used for acute toxicity test. Animals were divided into six groups of threerats each. Group A served as the control group while the other groups were dosed orally with 200, 500, 1000, 2000 and 5000mg/kg body weight of extract and were...
The test method is based on a stepwise procedure, each step using 3 animals of each sex (the preferred species is rat). Animals are exposed in inhalation chambers to a pre‐defined concentration for 4 hours. Absence or presence of compound‐related mortality of the animals at one step will...
Acute toxicity of 1,4-butanediol (BAD) was evaluated in laboratory animals. The evaluation involved acute oral and dermal toxicity in rats, dermal and ocular irritation in rabbits, and skin sensitization in guinea pigs. The oral LD50 values for BAD were 1.83 g/kg and 2.00 g/kg, respectively...
Toxicological Test on Calcium Hyaluronate Methods: The toxicological characteristic of calcium hyaluronate was studied by mice acute toxicity test and a 30-day feeding test in rats. Results: LD50 ... GL Yang,TL Zhang,XP Guo,... - 《Food & Drug》 被引量: 8发表: 2009年 Shortcomings of LD50...
203 (Fish, acute toxicity test) and OECD No. 212 (Fish, short-term toxicity test on embryo and sac-fry stages) methodology. RESULTS: The results ... E Praskova,D Zivna,S Stepanova,... - 《Neuro Endocrinology Letters》 被引量: 8发表: 2012年 Application of Neutral Red Uptake Assay ...
The study investigated the acute, sub-chronic toxicity and gastrointestinal protective activity of a polyherbal formulation (Mystomate4®) used locally in Nigeria. Methods Oral LD50 and the sub-chronic toxicity test were determined in mice and rats. Mice were grouped into 8 groups of 8 mice ...
toxicity of the test substance, sufficient safety information should be obtained from rodents and non-rodent animals. Therefore, the acute toxicity test should use at least two mammals. Generally, one rodent plus one non-rodent should be selected for acute toxicity test. If non-rodent animals ...
(LPA).Methods We experimented with animals for hemolytic test,muscular and venous stimulative test,allergic test,pyrogen test and acute toxicological test.Results The preparation of LPA was reliable and safe;with no LD50 detected during acute toxicological test.The maximum tolerance dose was 200 g /...
Acute oral toxicitytest assesses the health hazard effects of the test substance when orally administered to the test animals once or several times within 24 hours. Acute dermal toxicitytest assesses the health hazard effects of continuous skin contact with the test su...