The article reports on the development of a portable analyzer for testing toxicity in humans in Washington. Previously, laboratory personnel test toxicity by taking blood sample and analyze it in the laboratories by using plasma mass spectrometry, an expensive and time-consuming procedure. But with ...
Bisphenol A (BPA) has been widely used for manufacturing polycarbonate plastics and epoxy resins and has been extensively tested in animals to predict human toxicity. In order to reduce the use of animals for toxicity assessment and provide further accurate information on BPA toxicity in humans, ...
In subject area: Medicine and Dentistry Toxicity testing is a descriptive exercise and may be defined as the formalized process of exposing animals to a hitherto unknown or uncharacterized chemical for the purposes of characterizing the potentially harmful effects of that chemical. From: Acute Toxicolog...
The limitations of traditional toxicity testing characterized by high-cost animal models with low-throughput readouts, inconsistent responses, ethical issu
Shuhendler, A., Pu, K., Cui, L.et al.Real-time imaging of oxidative and nitrosative stress in the liver of live animals for drug-toxicity testing.Nat Biotechnol32, 373–380 (2014). https://doi.org/10.1038/nbt.2838 Download citation ...
In 1972, on the basis of dataontoxicitytofish and migrating birds (but nottohumans),the United States Environmental [...] project-syndicate.org project-syndicate.org 1972年,以对鱼类和候鸟(而非对人类)的毒性研究为依据,美国环境保护署全面禁止使用DDT,一种曾被广泛使用来杀灭致病虫害的廉价而有效的...
Brown, J. P., G. W. Roehm&R. J. Brown. 1978. Mutagenicity testing of certified food colors and related azo, xanthene and triphenylmethane dyes with the Salmonella/microsome system. Mutation Res. 56: 249–271. PubMedCASGoogle Scholar ...
But animal testing takes a long time and entails the deaths of animals to ac... ARNAUD,C Henry - 《Chemical & Engineering News》 被引量: 3发表: 2007年 Selenium Toxicity to Animals and Humans in Northwestern India-A Case Study In 1984-1985,when wheat plants showing extraordinarily white ...
Mutations in fused in sarcoma (FUS) lead to amyotrophic lateral sclerosis (ALS) with varying ages of onset, progression and severity. This suggests that unknown genetic factors contribute to disease pathogenesis. Here we show the identification of muscleblind as a novel modifier of FUS-mediated neu...
the metabolic and toxicological properties of drug compounds. Current in vitro models such as primary hepatocytes suffer from inconsistent availability and significant phenotypic variability. In vivo animal models are prohibitively expensive, have low throughput, and are often not predictive for humans. ...