Following the initial response to irinotecan, secondary resistance is acquired relatively rapidly, compromising its efficacy. There are several mechanisms contributing to the resistance, which affect the irinotecan metabolism or the target protein. In addition, we have demonstrated a major resistance ...
Methods: Viability assays were used to evaluate breast cancer cell sensitivity to topotecan and other TOP1 inhibitors as well as TOP2 inhibitors. An in vitro-derived topotecan-resistant TNBC cell model and TNBC xenograft models were employed to confirm cancer cell response to TOP1 blockade. RNA-...
摘要 目的总结Top1抑制剂与Tdp1抑制剂整体概况,探究其发展趋势,为后续研究提供参考。方法运用CiteSpace 5.7.R5软件对2012年1月—2022年4月收录在Web of Science(WOS)核心合集数据库中...展开更多 Objective To overall overview Top1 inhibitor and Tdp1 inhibitors and their development to provide reference for ...
ATC编码 L01CE 类别(英文) Topoisomerase 1 (TOP1) inhibitors 中文类别/限定日剂量 暂无权限 VIP试用医疗器械查询APP下载客服中心常见问题数据可视化数据分析挖掘系统网站地图业务介绍友情链接 400-678-0778 投诉热线: (023) 6262 8397 邮箱: tousu@yaozh.com QQ: 236960938 友情链接: 药物在线 药品...
adenocarcinoma (PDAC). Together, these important steps bring us one step closer to building a portfolio of potentially improved therapeutic combinations for PDAC patients with high unmet medical needs.” Overview: The combination of VCN-01 + topoisomerase I (topo1) inhibitors, such as liposomal ...
What evidence supports the use of Topoisomerase 1 (TOP1) inhibitors in reducing disease pathology in animal models of Coronavirus Disease 19 (COVID-19)? What inflammatory cytokines are hyper-activated during Strainssars Related Coronavirus 2 (SARS-CoV-2) infection?
POMMIER Y. Topoisomerase Ⅰ inhibitors: camptothecins and beyond[J]. Nat Rev Cancer, 2006, 6(10): 789-802. MCKENZIE J A, MBOFUNG R M, MALU S, et al. The effect of topoisomerase Ⅰ inhibitors on the efficac...
inhibitors of CHEK1, KRAS, and tyrosine kinase inhibitor showed higher synergistic efficacy than Patritumab-GGFG-DXd. Pharmacokinetic and safety profiles of AMT-562 were favorable and the highest dose lacking severe toxicity was 30 mg/kg in cynomolgus monkeys. AMT-562 has potential to be a super...
TOP1ccs are also selectively trapped by CPT and its derivatives topotecan and irinotecan used as anticancer drugs, which act as interfacial inhibitors and create a DNA-CPT-TOP1 ternary complex (Pommier, 2006). CPTs slow down the re-ligation step but do not directly cause a mis-alignment of ...
topotecan. The establishment and validation of an easy-to-use TDP1 enzymatic assay in cell extracts could be exploited as a diagnostic tool in the clinic. These findings may help in stratifying patients that are likely to benefit from TOP1 poisons and TDP1 inhibitors currently under developm...