Wu JQ, Guo JY, Tang W, Yang CS, Freel CD, Chen C, Nairn AC, Kornbluth S. PP1-mediated dephosphorylation of phosphoproteins at mitotic exit is controlled by inhibitor-1 and PP1 phosphorylation. Nat Cell Biol. 2009; 11 :644–51. doi: 10.1038/ncb1871. [ Cross Ref ]...
Raf1 phosphorylate inhibitor 1 (I-1), a potent PP1 inhibitor, avoids RIG-I/MDA5 activation. In late MeV infection, protein V prevents MDA5 dephosphorylation by acting as a PP1-substrate. In α-CoV infections, the nsp7 binds to MDA5 N-terminus and blocks its dephosphorylation by PP1. ...
PP1是一种有效的选择性Src家族抑制剂,抑制Lck和Fyn,IC50分别为5和6nM。注:本品仅可用于科研实验,严禁用于临床医疗及其他用途!CAS号:172889-26-8别名:AGL 1872;EI 275纯度:99.68%分子式:C16H19N5分子量:281.36结构式:储存条件:-20℃,有效期2年,溶入溶剂后-20℃请尽量在一个月内使用。相关搜索:Src家族抑制...
OC-1 was dosed orally in all in-vivo models.Results:We have discovered a novel small molecule inhibitor of ENPP1, OC-1, with a Ki value less than 10 nM in an ENPP1 enzymatic assay. Increase in gene expression of IFN-β and CXCL10/IP10 was observed in OC-1-treated THP1 cells. ...
PP1 (Src Inhibitor) 供应商 Cayman Chemical 产品货号 14244-5 产品报价 ￥询价/5mg 产品说明书 点击查看 购买方式 银行转账、电汇、支票、现金,在线支付宝及网银支付,或直接与我们电话联系400-6800-868 产品新闻 背景资料 Cayman Chemical是生化小分子标准品专家,艾美捷作为中国区域总代理,提供Cayman Chemical原装进...
PP1 (Src Inhibitor) 供应商 Cayman Chemical 产品货号 14244-1 产品报价 ￥询价/1mg 产品说明书 点击查看 购买方式 银行转账、电汇、支票、现金,在线支付宝及网银支付,或直接与我们电话联系400-6800-868 产品新闻 背景资料 Cayman Chemical是生化小分子标准品专家,艾美捷作为中国区域总代理,提供Cayman Chemical原装进...
The ectoenzyme PC-1 is an insulin receptor inhibitor that is elevated in cells and tissues of humans with type 2 diabetes (T2D). We have recently shown that acute PC-1 overexpression in liver causes insulin resistance and glucose intolerance in mice (3), but the chronic effects of PC-1 ...
2、1. T.U. Marron, et al. Preliminary safety, pharmacokinetics and immunomodulatory activity of RBS2418, an oral ENPP1 inhibitor, alone and in combination with pembrolizumab in patients with solid tumors. 1025MO. END 【智药研...
Salubrinal是一种磷酸酶(PP1)抑制剂,作用于真核生物翻译起始因子2亚基(eIF2α),抑制PP1活性,IC50?为1.7μM。 注:本品仅可用于科研实验,严禁用于临床医疗及其他用途! CAS号:405060-95-9 纯度:99.58% 分子式:C21H17Cl3N4OS 分子量:479.81 结构式: ...
b HT-29 and PPP1R3G-KO-1 cells were treated with DMSO or T/S/Z, in the presence of an increasing concentration of different inhibitors, followed by CellTiter-Glo assay. Viable cells expressed as a percentage of DMSO-treated cells. SB202190 is a p38 inhibitor, and TPCA-1, BMS345541 ...