What is the optimal duration, dose and frequency for anti-PD1 therapy of non-small cell lung cancer?checkpoint inhibitordosedurationimmunotherapynon-small cell lung cancerovertreatmentOver the past decade, immune checkpoint inhibitors (ICIs) have transformed the management of ...
However, the negative results of the phase III clinical trial of the would-be first-in-class IDO1 inhibitor (epacadostat) in combination with an anti-PD1 antibody (pembrolizumab) in patients with advanced malignant melanoma call for a better understanding of the role of IDO1 inhibition. In ...
as those tumor progressions with a minimum two-fold increase in tumor growth rate (TGR) after initiation of therapy compared to the pretherapy TGR [24]. In this study, 218 patients with different types of cancers were treated with anti-PD1 or anti-PD-L1 antibody monotherapy. Among 131 patie...
However, the negative results of the phase III clinical trial of the would-be first-in-class IDO1 inhibitor (epacadostat) in combination with an anti-PD1 antibody (pembrolizumab) in patients with advanced malignant melanoma call for a better understanding of the role of IDO1 inhibition. In ...
T-VEC is currently being evaluated as a potential treatment in melanoma and other advanced cancers [19, 20]. In a pre-clinical study in breast cancer bearing mice, the combination of an anti-PD1 antibody and a multi-peptide vaccine prolonged the vaccine-induced progression-free survival (PFS)...
Its role in the immune response against cancer is controversial. Finally, a subset of CD4+ T cells called regulatory T cells (Tregs) and characterized by the expression of CD25 and Foxp3, inhibit the immune response and represent a widely described mechanism whereby the tumor can escape the ...
However, the negative results of the phase III clinical trial of the would-be first-in-class IDO1 inhibitor (epacadostat) in combination with an anti-PD1 antibody (pembrolizumab) in patients with advanced malignant melanoma call for a better understanding of the role of IDO1 inhibition. In ...
[18]. T-VEC is currently being evaluated as a potential treatment in melanoma and other advanced cancers [19,20]. In a pre-clinical study in breast cancer bearing mice, the combination of an anti-PD1 antibody and a multi-peptide vaccine prolonged the vaccine-induced progression-free survival...
Their phenotype is now characterized by the increased expression of specific markers, including PD1, TIM-3 (h). Furthermore, a change in NF-kB composition occurs. In particular, its pro-inflammatory heterodimer (including the components p65 and p50) is replaced by an anti-inflammatory homodimer ...
Single-cell RNA sequencing (scRNA-seq) is a tool for studying gene expression at the single-cell level that has been widely used due to its unprecedented high resolution. In the present review, we outline the preparation process and sequencing platforms for the scRNA-seq analysis of solid tumor...