Several completed and ongoing clinical trials showed that nivolumab used alone or combined with chemotherapy or CTLA-4 inhibitor ipilimumab exhibited better effica-cy when compared with current clinical used chemotherapy drugs in the treatment of melanoma, non-small cell lung cancer and renal cell ...
blocking the interaction with PD-1 and CD80 molecules [54,55]. The compound is uniquely engineered to prevent antibody-dependent cell-mediated cytotoxicity on T cells expressing PD-L1. Durvalumab is a potent inhibitor with subnanomolar activity [PD...
of anlotinib combined with PD-1 inhibitors in the treatment of esophageal cancer was summarized.[Key words] Anlotinib; PD-1 inhibitor; Esophageal cancer 食管癌是一种比较常见的消化道肿瘤，发病率 及病死率均较高，多发生在40岁以上的人群中[1]。食管癌在恶性肿瘤中具有较高发病率，被认为是威胁人类...
Pembrolizumab is a programmed death receptor-1 (PD-1) blocking monoclonal antibody. It can block the immunosuppression mediated by the PD-1 pathway through blocking the interactions between PD-1 and PD-L1/PD-L2, and play a role in tumor immune function. It was the first PD-1 inhibitor appr...
PD-1抑制剂是近几年抗肿瘤药物里面的“超级大明星”,如人们常说的K药和O药。传统的细胞毒类药物虽然抗肿瘤谱广,但是安全性不足,而抗体类靶向药物大都抗肿瘤谱窄。PD-1抑制剂则打破这一“潜规则”,它通过调动人体免疫系统杀死肿瘤细胞,能针对绝大部分肿瘤起效,它...
1.Checkpoint Inhibitor Proliferation Like 'Wild West,' SaysFDA https://www.medscape.com/viewarticle/965074 2.Beaver JA, Pazdur R. The Wild West of Checkpoint Inhibitor Development. N Engl J Med. 2021 Dec 15. 3.Beaver JA, Pazdur R. "Dangling" Accelerated Approvals in Oncology. N Engl ...
(mAbs) that target PD-1/PD-L1, their unsatisfactory therapeutic effects may be due to the inability of mAbs to reach to intracellular POIs [5]. Another approach is small molecular inhibitor drugs, but these require a very strong interaction with POIs in order to be effective [6]. In ...
PD-1抑制剂神助攻 PD-1抑制剂是近几年抗肿瘤药物里面的“超级大明星”,如人们常说的K药和O药。传统的细胞毒类药物虽然抗肿瘤谱广,但是安全性不足,而抗体类靶向药物大都抗肿瘤谱窄。PD-1抑制剂则打破这一“潜规则”,它通过调动人体免疫系统杀死肿瘤细胞,能针对绝大部分肿瘤起效,它另一大特点是可以与大部分抗...
从技术层面,紫杉醇类药物取代了蒽环类药物,成为新的经典,主导肿瘤化学治疗20多年之久,在酪氨酸激酶抑制剂(tyrosine kinase inhibitor,TKI)药物和肿瘤免疫治疗(immuno-oncology,IO)来临之前,依然是肿瘤化学治疗的骨干药物。 依照美国FDA批准的泰素适应症分别为治疗二线...
can be applied to study the interactions between the molecules (e.g. PD-1/PD-L1 inhibitor) and their featured interfaces [83,84]. Nuclear magnetic resonance (NMR) NMR is a powerful tool to determine the structure, dynamics, and biomacromolecule interactions. NMR can also detect the binding ...