11.Zak KM, Grudnik P, Guzik K, et al. Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1). Oncotarget. 2016;7(21):30323-30335. 12.Lu, CH., Chung, WM., Tsai, CH. et al. In vitro characterization o...
2个月之后胸部CT显示双肺肿瘤几乎消失，腹部增强核磁显示肝脏病灶也缩小。迄今为止，患者仅仅进行PD-1抑制剂纳武利尤单抗的单药治疗，在2022年5月最后一次复查的时候，肝脏和肺部肿瘤完全消失，达到了完全缓解。目前患者身体状况良好，已经无病生存41个月了。总生存期已经达到了106个月（8.8年）。三、为何患者会有效...
肿瘤免疫治疗药物Programmed cell death protein 1 (PD-1) inhibitor拮抗剂是诸多肿瘤免疫治疗位点中较为成熟的一个,被称为继小分子靶向化药后的新一代肿瘤治疗药。PD-1拮抗剂具有较好的广谱性,未来将成为肿瘤治疗革命性的突破,将成就若干个重磅药。 1. 目前该靶点治疗药只有两个已经上市,分别为默克公司pembrolizu...
严格来讲,PD-1并不是药物,而是位于免疫细胞表面的一种免疫检查点,其对应药物应该叫PD-1抑制剂或PD-1单抗,统称为免疫检查点抑制剂(Immune checkpoint inhibitor),是免疫疗法之一。 传言它没有化疗药物那般在体内一通乱杀的狠劲,而是可以调动人体自身...
[4]. Cortazar, Frank B.et al. Clinical Features and Outcomes of Immune Checkpoint Inhibitor–Associated AKI: A Multicenter Study. JASN, 2020.31(2):p 435-446.[5] Hirsch, Jamie S. et al. Use of Immune Checkpoint Inhibitors in End Stage Kidney Disease Patients, Single Center Experience and...
12.Lu, CH., Chung, WM., Tsai, CH. et al. In vitro characterization of a small molecule PD-1 inhibitor that targets the PD-l/PD-L1 interaction. Sci Rep 12, 303 (2022).
Adverse effects of immune-checkpoint inhibitors: epidemiology, management and surveillance. Nature Reviews Clinical Oncology (2019).[3] Li, L., Li, G., Rao, B. et al. Landscape of immune checkpoint inhibitor-related adverse events in Chinese population. Sci Rep 10, 15567 (2020).（黄思宇）
Yang Song et al, Case Report: Genetic and immune microenvironmental characteristics of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis who achieved complete remission after treatment with PD-1 inhibitor, Front Immunol. 2023 Jul 13; ...
Spranger et Nature. (2015) Roche’s PD L1 inhibitor Tecentriq: a new contender in non small cell lung cancer, Clarivate Analysis. PD-1/L1 抑制剂治疗肿瘤的瓶颈及其发展趋势 | 美柏研究mp.weixin.qq.com/s/mjeqGtgiqTmIXlxQnFloeQ发布于 2018-11-27 20:08...
PD1-PDL1inhibitor1是PD-1/PD-L1蛋白/蛋白相互作用的抑制剂,是一种免疫调节剂。 注:本品仅可用于科研实验,严禁用于临床医疗及其他用途! CAS号:1675201-83-8 别名:PD-1/PD-L1 inhibitor 1 纯度:99.85% 分子式:C??H??NO? 分子量:475.58 结构式: ...