中文名称:化合物 Top1 inhibitor 1 英文名称:Top1 inhibitor 1 CAS:2302772-05-8 品牌: TargetMol 产地: 美国 保存条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. 产品类别: 抑制剂 货号: T13183 Product Introduction Bioactivity 名称 Top1 inhibitor ...
作者首先在拟南芥中应用TOP1抑制剂（TOP1i, TOP1 inhibitor）建立了一个反映R-loop水平与基因组拓扑状态的监测系统，发现CPT处理可显著促进根尖组织中基因组R-loop（拓扑结构发生改变导致的R-loop变化，简称为topoR-loop）水平和DNA断裂标记γH2AX水平的升高，并最终抑制根生长。利用CPT进行反向遗传筛选发现DNA损伤修复...
Top1 inhibitor 1 is a potent inhibitor of human topoisomerase I (Top1)(IC50: 29 nM). 规格价格库存数量 25 mg ¥ 10,600 6-8周 50 mg ¥ 13,800 6-8周 100 mg ¥ 17,500 6-8周 大包装 & 定制 TargetMol 的所有产品仅用作科学研究或药证申报,不能被用于人体,我们不向个人提供产品和服...
中文名TOP1 INHIBITOR 1 英文名Top1 inhibitor 1 别名化合物 T13183 英文别名Top1 inhibitor 1 4-Quinolinamine, N-[3-(1H-imidazol-1-yl)propyl]-6-(4-methoxyphenyl)-3-(1,3,4-oxadiazol-2-yl)- Top1 inhibitor 1,Top-1 inhibitor 1 CAS2302772-05-8 ...
英文名称:Top1 inhibitor 1 品牌厂商性质产地货期 MedChemExpress (MCE)生产商美国现货 性能特点 Top1 inhibitor 1 (化合物 28) 是一种有效的人拓扑异构酶 1 (Top1) 抑制剂,IC50 值为 29 nM。 在线咨询 询底价 AI问答 配套的仪器设备?可以搭配的相关耗材试剂?
To determine whether inhibition of TOP1 activity phenocopies depletion of TOP1 and dampens inflammatory gene expression, we treated SARS-CoV-2-infected A549-ACE2 cells with topotecan (TPT), a US Food and Drug Administration (FDA)-approved TOP1 inhibitor. TPT treatment, unlike DMSO treatment, ...
ASAP1, and MUC18, among others. MUC18 was overexpressed in both tumor cells and tumor-infiltrating blood vessels across major melanoma subtypes, making it a potential dual-compartment and universal melanoma therapeutic target. AMT-253, an MUC18-directed ADC based on topoisomerase I inhibitor exatec...
2024 年 2 月 20 日,上海市卫生健康委员会消化系统肿瘤全程监测与精准干预重点实验室(SMHC)/复旦大学附属闵行医院的研究团队在 Cell Reports Medicine(IF14.3)期刊发表了题为:Disruption of MerTK increases the efficacy of checkpoint i...
UNOH Y,UEHARA S,NAKAHARA K,et al. Discovery ofS-217622 , a noncovalent oral SARS-CoV-2 3CL proteaseinhibitor clinical candidate for treating COVID-19[ J]. J MedChem.等等。 想要解锁更多药企信息吗?查询药融云数据库(vip.pharnexcloud.com/?zmt-mhwz)掌握药企公司基本信息、投融资情况、产品管线分...
(FGF)-1 promotes proliferation and differentiation of human preadipocytes and recently demonstrated that bone morphogenetic protein and activin membrane-bound inhibitor (BAMBI) is a central, proximal effector. Herein, we describe the identification and characterization of carboxypeptidase X (CPX)-1, a ...