Label-free biosensor assay decodes the dynamics of Toll-like receptor signaling Toll-like receptors are key mediators of immune responses, but gaps remain in understanding their signalling. Here, the authors introduce an optical biosensor assay to detect real-time TLR activation and signalling dynamics...
Toll-like receptors (TLRs) arc a family of evolutionarily conserved, integral membrane glycoproteins that play a key role in innate immunity through the early sensing of pathogens and the initiation of appropriate responses. Each TLR receptor recognizes conserved motifs in macromolecular components from ...
TLR，即Toll-like receptor，是一种存在于巨噬细胞、树突状细胞和上皮细胞表面的受体，它们的主要功能是识别病原体相关的分子模式（PAMPs）和损伤相关的分子模式（DAMPs）。当这些模式与TLR结合时，它们启动了一种细胞内的信号传导过程。这个信号传导途径在固有免疫系统的激活中起着关键作用。首先，它促使...
TLR8重组蛋白是一种重组表达的Toll样受体(Toll-like receptor，TLR)家族成员，在免疫系统中扮演着重要的角色。作为一种免疫受体，TLR8可以感知特定的外源分子，启动信号转导途径，并引发机体的免疫应答。在生物学功能上，TLR8重组蛋白具有多种重要的作用，包括参与抗微生物防御、调节炎症反应、促进免疫细胞活化等。目录...
scavenger receptor TAB: transforming growth factor-β-activated kinase 1-binding protein TBK1: TRAF family member-associated NF-κB activator-binding kinase 1 TIR: Toll/interleukin-1 receptor TLR: Toll-like receptor TNF: tumor necrosis factor ...
TLRs characterized so far activate the MyD88/interleukin-l receptor-associated kinase (IRAK) signalling pathway. Genetic, gene-transfer and dominant-negative approaches have involved TLR family members (TLR2 and TLR4) in Gram-positive and Gram-negative bacteria recognition and signalling. Accumulating ...
Spector SA, Qin M, Lujan-Zilbermann J, Singh KK, Warshaw MG, Williams PLet al. Genetic variants in toll-like receptor 2 (TLR2), TLR4, TLR9, and FCgamma receptor II are associated with antibody response to quadrivalent meningococcal conjugate vaccine in HIV-infected youth.Clin Vaccine Immunol...
Toll-like receptor 4 (TLR4), a member of the Toll-like receptor (TLR) family, is involved in innate immunity and mediates inflammatory responses by recognizing lipopolysaccharide (LPS) or bacterial endotoxins. Hyperactivation of TLR4 triggers the production of various inflammatory factors, which a...
Toll-like receptors (TLRs) arc a family of evolutionarily conserved, integral membrane glycoproteins that play a key role in innate immunity through the early sensing of pathogens and the initiation of appropriate responses. Each TLR receptor recognizes conserved motifs in macromolecular components from ...
Toll like receptor 2 (TLR2) TLR2受体探针法荧光定量PCR试剂盒 产品及特点 Toll 样受体作为细胞表面的模式识别受体,能够对病原体识别、结合、引发一系列信号间的转导, 促进各种炎性介质的释放, 对宿主的天然免疫防御具有重要作用, 目前其家族成员至少有 11 个。TLR 与天然免疫应答关系的研究中, 倍受关注的是 ...