toll-like receptor signaling pway toll-like receptor signaling pathway是一种重要的免疫系统信号传导途径,它在宿主抵御感染和炎症调节中起着关键作用。本文将逐步介绍toll-like receptor(TLR)信号传导途径,并探讨其在免疫应答中的意义。 第一部分:导言(200-300字) 免疫系统是人体的防御机制,负责识别和清除有害的病...
Datla PraneelKshirsagar RajendraUpadhyay ShaktiPrasa Singh ShivaRajagopal VikramKanekar YogeshUpadhyay S, Kanetkar Y, Kshirsagar R, Rajgopal V, Datla P, Bellary A, et al. Toll like receptor (TLR) signaling antagonist. US Patent 20090215908, 27 August. 2009...
认为机体存在模式识别受体( pa他mreco趴i ti on receptor,PRR) ,特异地识别病原微生物进化中保守的抗原分子,即病原相关分子模式0athogen-associ ated m ol e∞l ar pa纰m ,PAM P) ,从而有效地监测病原微生物的入侵以及诱导机体免疫应答反应【l】.Tol l 样受体( Tol l 一l i kereceptor,TLRs) 就是...
The TLR-signalling pathways are negatively regulated by TLR-inducible molecules — such as IRAK-M (IL-1-receptor (IL-1R)-associated kinase M), SOCS1 (suppressor of cytokine signalling 1), MyD88s (MyD88 short), SIGIRR (single immunoglobulin IL-1R-related molecule) and ST2. ...
signalingreceptortlrsliketlrpathways VIEWPOINTToll-LikeReceptorSignalingPathwaysGregoryM.BartonandRuslanMedzhitov*MembersoftheToll-likereceptor(TLR)familyrecognizeconservedmicrobialstruc-tures,suchasbacteriallipopolysaccharideandviraldouble-strandedRNA,andactivatesignalingpathwaysthatresultinimmuneresponsesagainstmicrobialinfectio...
L. et al. Toll-like receptor 2 plays a critical role in maintaining mucosal integrity during Citrobacter rodentium-induced colitis. Cell. Microbiol. 10, 388–403 (2008). Article CAS PubMed Google Scholar Vora, P. et al. β-defensin-2 expression is regulated by TLR signaling in intestinal...
Toll like receptor 2 (TLR2) TLR2受体PCR试剂盒 ELISA试剂盒技术流程 双抗体夹心法(检测未知抗原) 间接法(检测未知抗体) 1、用缓冲液将抗体稀释至1-10ug/ml。在反应孔中加0.1ml,4℃ 过夜。次日,弃去孔内溶液,用洗涤缓冲液洗3次。 2、加样:加一定稀释的待检样品0.05ml于上述已包被之反应孔中,置37℃...
结论:TLR2信号通路参与吗啡诱导的神经元凋亡。【关键词】中毒性脑病;Toll—likereceptor2;吗啡;凋亡【中国图书分类法分类号】R742【文献标识码】A【收稿日期】2010—03—02TheroleofToll-likereceptor2anddownstreamingsignalinginopioids-mediatedapoptosisLIYi.etal(DepartmentofNeurology,theSecondAffiliatedHospital,SunYat...
《Toll-Like Receptor3（TLR3）在登革病毒诱导血管内皮细胞损伤中的作用》是依托中山大学，由黄俊琪担任项目负责人的面上项目。中文摘要 登革出血热（DHF）和登革休克综合征(DSS)与血管内皮损伤有关。我们研究发现DV诱导血管内皮细胞（EC）凋亡与Fas/FasL相关，DV感染后EC表面和胞内TLR3表达增加程...