百度试题 题目Toll样受体(Toll like receptor,TLR) 相关知识点: 试题来源: 解析 是一类病原体识别相关的受体,能与多种病原体及其产物结合,结合后通过激活细胞内的多条信号转导通路,在病原体感染引起的免疫和炎症反应中起重要作用。
近些年来有研究发现Toll样受体4(toll like receptor 4,TLR4)与Nod样受体蛋白3(nod-like receptor family pyrin domain-containing protein 3,NLRP3)炎性小体作为细胞炎症因子可以通过启动天然免疫,刺激相应的信号通路途径产生细胞因子和...
不同的TLRs亚家族识别不同的配体:TLR1与TLR2联合识别细菌的脂蛋白; TLR3识别病毒的双链 RNA和人工合成的双链 RNA聚肌胞苷酸(PolyI:C);TLR5识别细菌的鞭毛蛋白;TLR7识别某些免疫调节剂和抗病毒制剂;TLR8的结构和功能与TLR7相似;TLR9识别细菌和病毒DNA的CpG序列(CpG DNA)[5];TLR10的配体目前不甚清楚,基因组...
Toll like receptor, or TLR, plays a pivotal role in recognizing extracellular pathogens and triggering a series of signal transduction pathways to stimulate inflammatory介质释放 and initiate innate immune responses. Among the more than 10 TLR family members identified, TLR2 stands out as ...
多数情况下,刺激TLR引起炎性因子生成依赖于配体蛋白MyD88共同的途径,后者为35 ku的胞浆内蛋白质,是TLR/IL-1R超家族信号途径中普遍存在的接头蛋白,也是TLR/IL-1R超家族的重要成员之一。这种蛋白能通过胞浆内C末端Toll/IL-1受体(Toll/IL-1 receptor,TIR)区与TLR胞内尾端TIR区直接相连,并使其与促进信号进一步...
Toll-like receptors (TLRs) arc a family of evolutionarily conserved, integral membrane glycoproteins that play a key role in innate immunity through the early sensing of pathogens and the initiation of appropriate responses. Each TLR receptor recognizes conserved motifs in macromolecular components from ...
目的探讨新生小鼠巨细胞病毒(cytomegalovirus, CMV)感染后脾淋巴细胞 Toll样受 体(Toll-like receptor,TLR)2、9,髓样分化因子88(myeloid cell differentiation 88, MyD88),白细胞介 素(interleukin, IL)-2,干扰素-γ(interferon-γ,...
Toll like receptor 2 (TLR2) TLR2受体PCR试剂盒 ELISA试剂盒技术流程 双抗体夹心法(检测未知抗原) 间接法(检测未知抗体) 1、用缓冲液将抗体稀释至1-10ug/ml。在反应孔中加0.1ml,4℃ 过夜。次日,弃去孔内溶液,用洗涤缓冲液洗3次。 2、加样:加一定稀释的待检样品0.05ml于上述已包被之反应孔中,置37℃...
Toll-like Receptor AgonistsandInhibitors|PAMPS and DAMPS|TLR Structure|TLR Signaling|TLR Function|References TheToll-like receptors (TLRs)belong to a family of innate immune receptors known as pattern recognition receptors (PRRs), which includes Nod-like receptors (NLRs) and RIG-I like receptors (...
The interaction of Toll-like receptor 4 (TLR4) results in recruitment of proteinacious adapter molecules to the cell membrane. Here Hering and colleagues show that sphinganine recruits adaptor protein MyD88 to TLR4 in the macrophage membrane and the absence of sphinganine in murine models disrupts ...