TLRs在几乎存在于几乎所有细胞类型,尤其是具有免疫活性细胞。适应免疫反应是TLR信号触发和传导的结果。TLRs信号能增加抗原提呈。许多临床试验正在进行,以检测TLR激动剂作为增强血液肿瘤中抗肿瘤反应的潜在增强剂。 Overview of TLRs and TLR agonists TLRs的细胞外/细胞腔结构域,识别亮氨酸富集重复序列,这些化合物识别感染...
Waleed M Hussein,Tzu-Yu Liu,Mariusz Skwarczynski,Istvan Toth. Toll-like receptor agonists: a patent review (2011-2013)[J].Expert opinion on therapeutic patents 2014,4(4).Waleed M Hussein,Tzu-Yu Liu,Mariusz Skwarczynski,etc.Toll-like receptor agonists: a patent review (2011-2013)[J]....
(BCG), an extraction fromMycobacterium tuberculosis, activate both TLR2 and TLR4 – like LPS. For LPS, even the type of microbes it was derived from can affect its specificity12. Also, as both literature and our data showed, these established TLR agonists exerted high toxicity in vivo. ...
to the development of childhood-onset lupus. Mice that expressed one of these variants developed a lupus-like disease. UNC93B1 is known to regulate the localization of Toll-like receptors (TLRs) to the endosome, andUNC93B1variants resulted in enhanced responses to TLR7 and TLR8 agonists. ...
Toll-like Receptor AgonistsandInhibitors|PAMPS and DAMPS|TLR Structure|TLR Signaling|TLR Function|References TheToll-like receptors (TLRs)belong to a family of innate immune receptors known as pattern recognition receptors (PRRs), which includes Nod-like receptors (NLRs) and RIG-I like receptors (...
29]. Overexpression of TLR1 and TLR2 on MM cells enhances their adhesion to bone marrow stromal cells and their sensitivity to bortezomib and neutralizes the protective effect of bone marrow stromal cells over MM cells[30]. Toll-like receptor 2 forms heterodimers with either TLR1 or TLR6. ...
TLR2 is anchored to the cell membrane and resides on the cell surface, where heterodimerizes with either TLR1 or TLR6 to form the functional receptor [28]. One of the best characterized agonists of TLR2 are the lipopeptides, ubiquitous to all bacteria and highly expressed in the outer ...
Agonists that target toll-like receptors are being used clinically either alone or in combination with tumor antigens and showing initial success both in terms of enhancing immune responses and eliciting antitumor activity. This review summarizes the application of these adjuvants to treat cancer and ...
Viral infection and Toll-like receptor agonists induce a differential expression of type I and lambda interferons in human plasmacytoid and monocyte-derived dendritic cells.Viral infection and Toll-like receptor agonists induce a differential expression of type I and lambda interferons in human plasmacytoi...
like receptor 9 (TLR9) agonists have been extensively investigated as therapeutics in monotherapy or combination therapies for the treatment of cancer, infectious diseases and allergies. TLR9 agonists monotherapy shows limited efficacy in cancer patients; whereas, in combination with other therapies ...