产品活性:肿瘤坏死因子 α (TNF alpha) 是一种有效的促炎细胞因子。TNF alpha 与其受体结合,主要是 TNFR1 和 TNFR2,然后传递信号以实现炎症和细胞死亡等生物学功能。TNF alpha 通过 TNFR2 受体激活 NF-κB 通路促进癌细胞生长、侵袭和转移,但抗 TNF-α 抗体能显着抑制结肠炎相关癌症 (CAC) 小鼠的肿瘤发展。
EphB2, TNF-alpha, TNFR2, NF-kappaB, NeuroregenerationHIV-1 infected individuals are at high risk of developing HIV-associated neurocognitive disorders (HAND) as HIV infection leads to neuronal injury and synaptic loss in the central nervous system (CNS). The neurotoxic effects of HIV-1 are ...
Expression of TNF α and its receptors R1 and R2 in human alveolar epithelial cells exposed to organic dust and the effect of 8-bromo-cAMP and protein kinase A modulation. Inflamm Res 2005;54:281-8.Burvall K, Palmberg L, Larsson K. Expression of TNF alpha and its receptors R1 and R2 ...
Cui YH, LeY Zhang X, Gong W, Abe K, Sun R, Van Damme J, Proost P, Wang JM (2002) Up-regulation of FPR2, a chemotactic receptor for amyloid beta 1-42 (A beta 42), in murine microglial cells by TNF alpha. Neurobiol Dis 10(3):366–377...
Association between tumor necrosis factor (TNF)-α G-308A gene polymorphism and preeclampsia complicated by severe fetal growth restriction et al.Association between tumor necrosis factor (TNF)-alpha G-308A gene polymorphism and preeclampsia complicated by severe fetal growth restriction.Clinica ... A...
产品活性:肿瘤坏死因子 α (TNF alpha) 是一种有效的促炎细胞因子。TNF alpha 与其受体结合,主要是 TNFR1 和 TNFR2,然后传递信号以实现炎症和细胞死亡等生物学功能。TNF alpha 通过 TNFR2 受体激活 NF-κB 通路促进癌细胞生长、侵袭和转移,但抗 TNF-α 抗体能显着抑制结肠炎相关癌症 (CAC) 小鼠的肿瘤发展。
Sibson NR, Blamire AM, Perry VH, Gauldie J, Styles P, Anthony DC. TNF-alpha reduces cerebral blood volume and disrupts tissue homeostasis via an endothelin- and TNFR2-dependent pathway. Brain. 2002; 125(Pt 11):2446-59. Epub 2002/10/23. PMID: 12390971....
In situ localization of TNFalpha/beta, TACE and TNF receptors TNF-R1 and TNF-R2 in control and LPS-treated lung tissue. Cytokine. 2003;22(3-4):89-100.Ermert M, Pantazis C, Duncker HR, Grimminger F, Seeger W, et al. (2003) In situ localization of TNFalpha/ beta, TACE and TNF...
Association of TNF-alpha and TNFR1 promoters and 30 UTR region of TNFR2 gene polymorphisms with genetic susceptibility to tobacco-related oral carcinoma in Asian Indians. Oral Oncol 2008;44:455-63.Gupta R, Sharma SC, Das SN. Association of TNF‐alpha and TNFR1 ...
7-OMe-APBT透過活化caspase-8/mitochondria的死亡路徑引發細胞凋亡,進一步活化p38 MAPK致使TNF-α及TNFR2表現增加; p38 MAPK誘導c-Jun磷酸化導致TNFR2 promoter活性增加,預先處理p38 MAPK抑制劑 (SB202190)能抑制7-OMe-APBT上調TNFR2 promoter冷光活性及mRNA表現的效應;另一方面,7-OMe-APBT透過PP2Acα介導TTP的...