TNF-alpha-308 G allele was significantly lower (Pc=0.004; OR=3.85), whereas A allele was significantly higher (Pc=0.004; OR=0.25) in patients compared with controls. No significant change was observed at -238 promoter site between the two groups. In the case of TNF receptors, both TNFR1...
Critical role of TNF‑alpha‑TNFR1 signaling in intracranial aneurysm formation. Acta Neuropathol Commun 2014;2:34.Aoki T, Fukuda M, Nishimura M, et al.Critical role of TNF- alpha-TNFR1 signaling in intracranial aneurysm formation[J].Acta NeuropathologicaCommunications, 2014, 2(1): 3....
Immunolabelling showed the presence of TNF-alpha and TNFR1 in the sterile inflammation located mainly in the interradicular PDL area. More definitive labelling appeared in OPG-treated rats. The results indicated that TNF-alpha, and its receptor TNFR1, by their presence, may modify OPG ...
Superoxide anion-induced pain and inflammation depends on TNFα/TNFR1 signaling in mice cita-Borin FY, Zarpelon AC, Pinho-Ribeiro FA et al (2015) Superoxide anion-induced pain and inflammation depends on TNFalpha/TNFR1 signaling in mice... ...
Upon TNF-α binding, TNFR1 initiates pro-inflammatory responses and apoptosis, as it presents an intracellular death domain motif. Conversely, TNFR2, which does not possess an intracellular death domain, triggers cell survival and proliferation [25]. In the synovium of active RA patients, both ...
Designing a new dimerized anti human TNF-alpha aptamer with blocking activity With regard to the several limitations of anti-TNF-alpha proteins therapies including immunogenicity, side effects, and cost-intensive, a new designed anti-... ASM Mashayekhi - 《Biotechnology Progress》 被引量: 0发表: ...
TNFR1MacrophagesInnate immune systemNFkBIntroduction: The tight regulation of the cytokine network during macrophage activation is of prime importance to enable a fast and potent innate immune response against exogenous pathogens. The inflammation mediating ubiquitin-like protein HLA-F adjacent transcript ...
Huachansu suppresses human bladder cancer cell growth through the Fas/Fasl and TNF- alpha/ TNFR1 pathway in vitro and in vivo. J Exp Clin Cancer Res. 2015;34(1):21.Yang T, Shi R, Chang L, Tang K, Chen K, Yu G, Tian Y, Guo Y, He W, Song X, et al. Huachansu suppresses...
PCR array-based analysis of inflammatory cytokines indicated that COX2 upregulates the expression of TNF alpha. Subsequent rescue assays showed that an anti-TNF alpha monoclonal antibody could antagonize COX2-mediated MM cell proliferation and adhesion. Administration of NS398, a specific COX2 ...
Binding of TNF alpha to TNFR1 can lead to divergent signaling pathways promoting predominantly NF-kappa B activation but also cell death. We report here that the nitric oxide (NO) donor glyceryl trinitrate (GTN) converts TNF alpha, generated from immune cells or cancer cells stimulated by ...