这在当时是很让人困惑的,因为大家都觉得pro-inflammatory cytokines是有炎症存在,才会暂时性表达的。最后一路溯源,发现了TNF其实是所有的源头,因此TNF的研究从80s开始就热起来,TNF也被称为the apex of a pro-inflammatory cytokine cascade。TNF的抗体药物早在1980s就问世,在1990s期间参与临床试验(low dose methotrexat...
[8] Hao GH, Duan W, Sun JP, et al. Effects of febuxostat on serumcytokines IL-1, IL-4, IL-6, IL-8, TNF-α and COX-2[J]. Exp Ther Med, 2019, 17(1): 812-816. DOI:10.3892/et m.2018.6972. [9] Leon...
The article delves into a report stressing the significance of the pro-inflammatory cytokine tumour-necrosis factor (TNF) and its receptors to the regulation of immune responses on conditions with limited immunostimulatory capacity. It highlights the relation of the involvement of TNF in immunity to ...
Tumour necrosis factor (TNF) is a central cytokine in inflammatory reactions, and biologics that neutralize TNF are among the most successful drugs for the treatment of chronic inflammatory and autoimmune pathologies. In recent years, it became clear that TNF drives inflammatory responses not only dir...
近期有关于COVID-19病理生理学研究表明,细胞因子释放综合征(cytokine release syndrome,CRS)与疾病的严重程度密切相关,特别是TNF-α、IFN-γ、IL-6、IL-2、IL-15 和 IL-18等炎症因子释放增加。因此,抑制CRS的发生对于COVID-19重度患者的治疗来说将是一个非常有效的手段。其中,TNF-α和IFN-γ是两种重要的促炎...
ARTICLES nature publishing group See ARTICLE page 186 The TNF-family cytokine TL1A drives IL-13-dependent small intestinal inflammation F Meylan1,6, Y-J Song1,6, I Fuss2, S Villarreal1, E Kahle1, I-J Malm1, K Acharya1, HL Ramos3, L Lo4, MM Mentink-Kane5, TA Wynn5, T-S Mig...
1. Ware CF. The TNF Superfamily-2008. Cytokine Growth Factor Rev. 2008. 19(3-4):183-6. 2. Dostert C et al. The TNF Family of Ligands and Receptors: Communication Modules in the Immune System and Beyond. Physiol Rev. 2019. 99(1):115-160. ...
(n = 5 healthy and 4 RA). e, TNF as the predominant cytokine expressed by activated naive CD4+T cells. Transcripts for T cell effector cytokines in activated naive CD4+T cells are quantified by qPCR (n = 3). f, ...
*本图来源于Cytokine出版物[17]。 3.2 TNFR1-tmTNF-α信号通路 关于TNFR1-tmTNF-α的信号通路目前的研究机制尚不明确,有研究发现,TNFR1-tmTNF-α信号通路不同于TNFR1-sTNF-α,后者可介导生存或凋亡两种截然不同的信号途径。而TNFR1-tmTNF-α仅能介导细胞的凋亡,并不能激活NF-κB。虽然TNFR1与两型TNF结合...
Read the latest articles of Cytokine at ScienceDirect.com, Elsevier’s leading platform of peer-reviewed scholarly literature