TRANCE (tumor necrosis factor [TNF]–related activation-induced cytokine) is a new member of the TNF family that is induced upon T cell receptor engagement and activates c-Jun N-terminal kinase (JNK) after inte
TRANCE (TNF-related activation-induced cytokine) sRANKL 人 NFkB 配体可溶性受体激活剂 TRANCE(TNF 相关活化诱导细胞因子) 破骨细胞分化因子 产品介绍: 产品说明 一般描述 TRANCE(TNF 相关活化诱导细胞因子),也称为 sRANKL(可溶性核因子受体活化因子K-B 配体),由映射到人类染色体 13q14.11 的基因编码。 sRANKL...
MURINE TNF-RELATED ACTIVATION-INDUCED CYTOKINE - Names and Identifiers Name MURINE ODF Synonyms MURINE SOLUBLE RECEPTOR ACTIVATOR OF NFKB LIGANDMURINE ODFMURINE OPGLMURINE OSTEOCLAST DIFFERENTIATION FACTORMURINE OSTEOPROTEGERIN LIGANDMURINE SRANKLMURINE TNF-RELATED ACTIVATION-INDUCED CYTOKINEMURINE TNFSF11 ...
Tumour necrosis factor (TNF) is a central cytokine in inflammatory reactions, and biologics that neutralize TNF are among the most successful drugs for the treatment of chronic inflammatory and autoimmune pathologies. In recent years, it became clear tha
Here we identified TNFα induced by DNA sensing in macrophages as a major pro-inflammatory cytokine impairing RPE barrier function in vitro, so we sought to investigate molecular signals of TNFα activation from fresh human AMD donor samples. TNFα signature genes, including TNFAIP3, EGR1 and ...
3.1. EGF-induced MAPK activation is independent on TAK1 TAK1 has been shown to regulate MAPK pathways from cytokine receptors. However, the role in growth factor signaling pathways remains to be investigated. As reported previously, treatment of HeLa cells with TNF-α induced rapid phosphorylation...
[22] Stoffel E, Maier H, Riedl E, et al. Analysis of anti-tumour necrosis factor-induced skin lesions reveals strong T helper 1 activation with some distinct immunological characteristics[J]. Br J Dermatol, 2018, 178(5): 1151-1162. ...
Thioredoxin-mediated denitrosylation regulates cytokine-induced nuclear factor κB (NF-κB) activation J. Biol. Chem., 289 (2014), pp. 3066-3072 View PDFView articleCrossrefView in ScopusGoogle Scholar [27] Y.M. Kim, T.H. Kim, H.T. Chung, R.V. Talanian, X.M. Yin, T.R. Billiar...
The pro-inflammatory and anti-inflammatory properties of TNF are largely segregated by the capacity of this cytokine to bind to TNF receptor 1 (TNFR1) and TNFR2, respectively. The anti-inflammatory effects of TNF are explained by its capacity to increase the proliferation, stability and suppressiv...
Could sensitising resistant cancer cells to TNF-induced cell death be an effective strategy for the treatment of cancer? Introduction Tumour Necrosis Factor alpha (TNF) is a pro-inflammatory cytokine that plays a central role in regulating innate immune and inflammatory responses. Stimulation of cells...