Oral lichen planus (OLP) is a T cell-mediated inflammatory disease of the oral mucosa. T lymphocytes accumulate within OLP lesions by extravasation from the local microvasculature and subsequent migration to the oral epithelium. Tumor necrosis factor-alpha (TNF-α) is a cytokine involved primarily ...
Tumor necrosis factor alpha (TNF-alpha) is a pleiotropic proinflammatory cytokine that elicits a large number of biological effects, including inflammatory and immunoregulatory responses. Biological activities of TNF-alpha are mediated by two distinct TNF receptors, p55 type 1 receptor (TNFR1) and p75...
Tumor necrosis factor alpha (TNF-alpha), also known as TNF, TNFA or TNFSF2, is the prototypic cytokine of the TNF superfamily, and is a multifunctional molecule involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid meta...
Aggarwal BB (2003) Signalling pathways of the TNF superfamily: a double-edged sword. Nat Rev Immunol 3:745–756 Article PubMed CAS Google Scholar Wajant H, Henkler F, Scheurich P (2001) The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their ...
(also known as tumour necrosis factor alpha-induced protein 3) in intestinal epithelial cells to inhibit the inflammatory response and apoptosis mediated by some signal transduction pathways, such as NF-κB, and subsequent TNF-α production [116,117]. However, A20 is a potent inhibitor of NF-...
OPTN has been shown to regulate interferon induction, and TNFR (TNF-α receptor) signaling to the benefit or detriment of cells21,22,23. Much previous work on OPTN-dependent regulation of cytokine signaling has been performed in vitro, but our in vivo data shows tissue specific differences in...
TNF-α is a major cytokine implicated in rheumatoid arthritis. Its expression is regulated both at the transcriptional and posttranscriptional levels and r... N Semaan,L Frenzel,G Alsaleh,... - 《Plos One》 被引量: 142发表: 2011年 Characteristics of the Intron Involvement in the Mitogen-ind...
In this study, we show that human Vγ2Vδ2 T cell responses to phosphoantigen, including activation, proliferation, cytokine production, and tumor cell cytotoxicity, require TNF-α binding to its receptor, with a preference for TNFR2. Because stimulated Vγ2Vδ2 cells also produce TNF-α, ...
In that way, pre-tobacco influences on cytokine levels could be established, time to develop COPD would be recorded, and temporal relationships between body composition and cytokine profiles established. These possibilities could have therapeutic consequences, since a TNF-α blocking agent presumably ...
Cytokine profiling was determined by the multiplex immunoassay (a–c) or ELISA (d). a, b, Heat maps of indicated cytokine concentrations in the air pouch (a) and the serum (b) of injected mice. c, d, Cytokine concentrations in the serum shown as mean ± s.e.m. (two-tailed ...