Cancer-associated cachexia; Protein/DNA ratio; Intraperitoneal administration of TNF-alpha in gene-deficient mice.CarboN.BusquetsS.van RoyenM.AlvarezB.Lopez-SorianoF.J.British Journal of CancerCarbo N,Busquets S,van Royen M,et al.TNF-alpha is involved in activating DNA fragmentation in skeletal ...
TNF- αcancer cachexiaapoptosisIntraperitoneal administration of 100 microg kg(-1) (body weight) of tumour necrosis factor-alpha to rats for 8 consecutive days resulted in a significant decrease in protein content, which was concomitant with a reduction in DNA content. Interestingly, the protein/...
摘要: Investigates the role of tumor necrosis factor (TNF)-alpha in the fragmentation of muscle DNA. Cancer-associated cachexia; Protein/DNA ratio; Intraperitoneal administration of TNF-alpha in gene-deficient mice.被引量: 102 年份: 2002
protein is produced mainly by macrophages, and large amounts of this cytokine are released in response to lipopolysaccharide, other bacterial products, and Interleukin-1 (IL-1). TNF-alpha is involved in fighting against the tumorigenesis, thus, is regarded as a molecular insight in cancer ...
W7, a calmodulin-dependent protein kinase inhibitor, was inhibitory in all cases. Thus, MAI-induced TNF-alpha mRNA accumulation is of short duration and PKC dependent. MAI-induced TNF-alpha protein production is low, possibly resulting in a mitigated antimicrobial effect. 展开 ...
TNF-α may be a potential biomarker for predicting PR that could facilitate risk stratification and management in STEMI patients.Keywords: acute coronary syndrome, plaque rupture, plaque erosion, inflammation, TNF-α Graphical Abstract: Introduction Acute coronary syndrom...
Functional analysis of tumor necrosis factor (TNF) receptors in TNF-α mediated insulin resistance in genetic obesity. Endocrinology 139, 4832–4838 (1998). Article CAS Google Scholar Memon, R.A. et al. Up regulation of uncoupling protein 2 mRNA in genetic obesity: lack of an essential role...
作者: A Zganiacz 摘要: TNF-alpha has long been regarded as a proimmune cytokine involved in antimicrobial type 1 immunity. However, the precise role of TNF-alpha in antimicrobial type 1 immunity remains poorly understood. We found that TNF-alpha-deficient (TNF(-/-)) mice quickly succumbed ...
Tumor necrosis factorα (TNFα) is a pleiotropic cytokine which can regulate a wide variety of cellular responses. Low concentrations of TNFα seem to increase tumor growth and progression. The −308 G/A polymorphism in TNFα has been implicated in breast cancer risk but the published data ...
sid=HKU:IR&issn=0016-5085&volume=114&issue=4&spage=G2397&epage=&date=1998&atitle=TNF-a+and+IL-1b+induce+interleukin+8+response+in+human+gastric+epithelial+cells+and+the+signal+pathway+is+mediated+by+protein+tyrosine+kinase+and+dexameth-asone-sensitive+mechanism 10.1016/S0016-5085(98)82380...