In contrast, no significant alterations in TLR2 expression were observed with protein kinase C or p38 mitogen‐activated protein kinase inhibitors. A definitive role for TNF‐α was demonstrated by the inability of S. aureus to augment TLR2 expression in microglia isolated from TNF‐α knockout ...
Lower protein levels of TLR8 in monocytes from RSV-infected infants, compared to healthy infants, negatively correlated with respiratory frequency and resulted in lower TNF-?? synthesis upon a specific TLR8 stimulation. In the convalescent phase, levels of TLR8 increased, accompanied by increased ...
H2 significantly abolished the upregulation of LOX-1 by different stimuli, including TNF-α, at the protein and mRNA levels. The TNF-α-induced upregulation of LOX-1 was also attenuated by the NF-κB inhibitor N-acetyl-l-cysteine. H2 inhibited the TNF-α-induced activ...