Ablation of TNF-alpha-induced protein 3 (TNFAIP3), one of the crucial negative regulators of nuclear factor kappa B activation in myeloid cells and DCs, was shown to control DC activation. Objective: In this study we investigated the precise role of TNFAIP3 in myeloid cells for the ...
A20单倍体不足(haploinsufficiency of A20,HA20)是由于TNF-α诱导蛋白3(TNF alpha induced protein 3,TNFAIP3)基因变异引起A20蛋白不足的常染色体显性遗传病,以反复发热、口腔、生殖器和/或胃肠道溃疡为主要表现,可并发如系统性红斑狼疮、自身免疫性甲状腺疾病等自身免疫性疾病[18]。A20既发挥去泛素化作用,通过卵巢...
TNFAIP3 (TNF Alpha Induced Protein 3 or A20), was used as a marker of TNFα activity27,28. The TNFAIP3 expression was rapidly induced after 2 h of treatment with TNFα (Fig. 6A). Next, we measured several ISGs, including ISG15, DDX58, MX1 and OAS1 by qPCR, to indicate ...
TNFAIP3 (TNF Alpha Induced Protein 3 or A20), was used as a marker of TNFα activity27,28. The TNFAIP3 expression was rapidly induced after 2 h of treatment with TNFα (Fig. 6A). Next, we measured several ISGs, including ISG15, DDX58, MX1 and OAS1 by qPCR, to indicate ...
2004年Tausche等首次应用TNF-α拮抗剂依那西普治疗1例急性痛风性关节炎合并急性督功能衰竭的53岁男性,该患者曾尝试多种治疗(包括秋水仙喊、双氯芬酸钠、甲强龙及止痛药芬太尼等两失败,予以皮下注射依那西普25mg每周2次,连续应用2周后,...
Chestnut Studying 摘要 The endothelium is a major target of the proinflammatory cytokine, tumor necrosis factor alpha (TNFα). Exposure of endothelial cells (EC) to proinflammatory stimuli leads to …
2A): CXCL (C-X-C motif chemokine ligand) 1, CXCL5, CXCL8 and PPBP (Pro-Platelet Basic Protein); C-X-C ligand receptor: CXCR4 (C-X-C motif chemokine receptor 4); the NFκB inhibitors: NFKBIZ, NFKBID (NFKB inhibitor Zeta and Delta) and TNFAIP3 (TNF Alpha induced protein 3); ...
Recombinant Human TNF-alpha Protein 重组人肿瘤坏死因子-α 90635ES10 10 μg 90635ES50 50 μg 90635ES60 100 μg 90635ES80 1 mg 产品描述 肿瘤坏死因子-α(TNF-α)是一种多效性促炎细胞因子,由多种细胞分泌,包括脂肪细胞、活化的单核细胞、巨噬细胞、B细胞、T细胞和成纤维细胞。它属于TNF配...
2. Mohideen, F. et al. 2017. Quantitative Phospho-proteomic Analysis of TNFalpha/NFkappaB Signaling Reveals a Role for RIPK1 Phosphorylation in Suppressing Necrotic Cell Death. Mol Cell Proteom.3. Hideo Hagihara, et al. 2021. Protein lactylation induced by neural excitation. Cell Reports.4....
TNF alpha recombinant protein Cited in 64 papers. Free of endotoxin and animal components. Authentic glycosylation, maturation, and folding lead to greater stability and activity than CHO and E. coli systems.