TNFThalidomide (Thd) is clinically useful in a number of conditions where its efficacy is probably related to its anti-TNF-alpha activity. More recently, Thd has also been shown to co-stimulate T cells and second generation co-stimulatory (IMiD trade mark ) analogues are currently being ...
TNFalpha as therapeutic target: new drugs, more applications. TNF± is a crucial cytokine in the establishment and maintenance of inflammation in multiple autoimmune diseases. With the introduction of infliximab and e... Reimold - 《Current Drug Targets Inflammation & Allergy》 被引量: 140发表: ...
Cui YH, Le Y, Zhang X, Gong W, Abe K, Sun R, Van Damme J, Proost P, Wang JM (2002b) Up-regulation of FPR2, a chemotactic receptor for amyloid beta 1-42 (A beta 42), in murine microglial cells by TNF alpha. Neurobiol Dis 10:366 -377....
EphB2, TNF-alpha, TNFR2, NF-kappaB, NeuroregenerationHIV-1 infected individuals are at high risk of developing HIV-associated neurocognitive disorders (HAND) as HIV infection leads to neuronal injury and synaptic loss in the central nervous system (CNS). The neurotoxic effects of HIV-1 are ...
7-OMe-APBT透過活化caspase-8/mitochondria的死亡路徑引發細胞凋亡,進一步活化p38 MAPK致使TNF-α及TNFR2表現增加; p38 MAPK誘導c-Jun磷酸化導致TNFR2 promoter活性增加,預先處理p38 MAPK抑制劑 (SB202190)能抑制7-OMe-APBT上調TNFR2 promoter冷光活性及mRNA表現的效應;另一方面,7-OMe-APBT透過PP2Acα介導TTP的...
In situ localization of TNFalpha/beta, TACE and TNF receptors TNF-R1 and TNF-R2 in control and LPS-treated lung tissue. Cytokine. 2003 May;22(3- 4):89-100.Ermert M,Pantazis C,Duncker HR,Grimminger F,Seeger W,Ermert L. In situ localization of TNFalpha/beta, TACE and TNF ...
Association of TNF-alpha and TNFR1 promoters and 3′ UTR region of TNFR2 gene polymorphisms with genetic susceptibility to tobacco-related oral carcinoma in Asian Indians. Oral Oncol. 2008; 44 :455–463. doi: 10.1016/j.oraloncology.2007.06.003. [ Cross Ref ]...
Bruggeman LA, Drawz PE, Kahoud N, Lin K, Barisoni L, Nelson PJ (2011) TNFR2 interposes the proliferative and NF-kappaB-mediated inflammatory response by podocytes to TNF-alpha. Lab Invest 91:413–425Bruggeman LA, Drawz PE, Kahoud N, Lin K, Barisoni L, Nelson PJ. TNFR2 interposes...
(2011). TNFα-induced IP3R1 expression through TNFR1/PC-PLC/PKCα and TNFR2 signalling pathways in human mesangial cell. Nephrol. Dial. Transplant. 26, 75-83. doi: 10.1093/ndt/gfq406Wang YR, Li ZG, Fu JL, Wang ZH, Wen Y & Liu P (2011). TNFalpha-induced IP3R1 expression through...
Sibson NR, Blamire AM, Perry VH, Gauldie J, Styles P, Anthony DC: TNF- alpha reduces cerebral blood volume and disrupts tissue homeostasis via an endothelin- and TNFR2-dependent pathway. Brain 2002, 125:2446-2459.Sibson NR, Blamire AM, Perry VH, et al. TNF-alpha reduces cerebral blood...