TARGETED ONCOLOGY:What’s currently known about the efficacy of immunotherapies to treat TNBC? What makes TNBC unique? Rugo: We don't really know that TNBC is unique, actually. We know that the mutational load of TNBC is higher than other subsetsyou increase mutations and resistance over ...
[Harnessing immunogenicity] is sorely needed because women who have metastatic TNBC have a very poor prognosis with standard chemotherapy. Standard treatments lead to a median survival of 1 year, which is very short. We hope that using immunotherapies to stimulate the immune system is going to cha...
The immune system (IS) may play a crucial role in preventing tumor development and progression, leading, over the last years, to the development of effective cancer immunotherapies. Nevertheless, immune evasion, the capability of tumors to circumvent destructive host immunity, remains on...
Beyond conventional immune-checkpoint inhibition - novel immunotherapies for renal cell carcinoma. Nat Rev Clin Oncol. 2021;18(4):199–214. Article CAS PubMed PubMed Central Google Scholar Perets R, Bar J, Rasco DW, Ahn MJ, Yoh K, Kim DW, et al. Safety and efficacy of quavonlimab,...
Immunotherapies Spark Excitement in Triple-Negative Breast Cancer Treatment Tony Berberabe, MPH March 8th 2025 Article Immunotherapy advances in triple-negative breast cancer drive personalized treatments with immune checkpoint inhibitors, aiding subtype identification and new combination therapy developments. ...
Combination therapies targeting both the CD155/TIGIT axis and metabolic pathways could potentially enhance the efficacy of immunotherapies and metabolic interventions. Developing such strategies requires a comprehensive understanding of the intricate molecular mechanisms underlying these processes, emphasizing the ...
Pyroptosis mediated by gasdermin protein has shown great potential in cancer immunotherapies. However, the low expression of gasdermin proteins and the sys... X Wang,W Zhang,Y Wang,... - 《Acs Nano》 被引量: 0发表: 2024年 UNVEILING THE MECHANISTIC INSIGHTS OF ARGININE DEPRIVATION COMBINED WITH...
Pyroptosis mediated by gasdermin protein has shown great potential in cancer immunotherapies. However, the low expression of gasdermin proteins and the sys... X Wang,W Zhang,Y Wang,... - 《Acs Nano》 被引量: 0发表: 2024年 UNVEILING THE MECHANISTIC INSIGHTS OF ARGININE DEPRIVATION COMBINED WITH...
Chitinase-like proteins (CLPs) play a key role in immunosuppression under inflammatory conditions such as cancer. CLPs are enzymatically inactive and become neutralized upon binding of their natural ligand chitin, potentially reducing CLP-driven immunosu
Therefore, continuously searching for new targeted therapies and immunotherapies becomes a focus in TNBC treatment in patients with diverse communities. The studies showed that TNBC is more immunogenic than other subtypes of breast cancers with tumor-infiltrating lymphocytes (TILs) in its microenvironment....