This medicine is a checkpoint inhibitor used for high-risk, early-stage, triple-negative breast cancer (TNBC). It's done along with chemotherapy. It can also be given to treat metastatic TNBC when the tumor makes PD-L1 protein. Surgery ...
The present invention relates to a method of treating TNBC in a patient by administering to the patient a drug that inhibits the expression or activity of cyclin-dependent kinase 19 (CDK19). In some embodiments, the agent may be a small molecule inhibitor, polynucleotide (eg, shRNA, siRNA)...
It’s more difficult to treat because it lacks receptors to target. TNBC is less common than the other subtypes and is more often seen in Black women. It is associated with the BRCA1 genetic mutation, known to increase the risk for breast cancer, but most people with TNBC will not have...
ReviewHow shall we treat early triple-negative breast cancer (TNBC): from the current standard to upcoming immuno-molecular strategies Author links open overlay panelJi Hyun Park 1 2, Jin-Hee Ahn 1, Sung-Bae Kim 1Show more Add to Mendeley Share Cite...
Learn how KEYTRUDA® (pembrolizumab) works with your immune system to help fight cancer cells. Watch two videos about immunotherapy and how it works in the body.
Triple-negative breast cancer (TNBC) remains one of the most challenging subtypes of breast cancer to treat due to a lack of effective targeted therapies. ... Lauren K. Somes,Jonathan T. Lei,Xinpei Yi,... 被引量: 0 Abstract #4892: PTEN/PI3K/Akt pathway regulates the side population ...
ER+PR−HER2− tumours of high grade and advanced stage showed particularly high breast cancer mortality similar to TNBC. When examining early versus late mortality, grade, size and nodal status explained most of the late (> 5 years) mortality among ER+ subtypes. Conclusions There is a...
aBeals isn't about to give up what happens in the end. But she says she'll miss the show and the cast. Beals不将放弃什么在最后发生。 但她说她将错过展示和塑像。[translate] aClinicopathological and prognostic characteristics of triple- negative breast cancer (TNBC) in Chinese patients: a ret...
Such results stress the importance of performing studies to evaluate the concordance between different methods for identifying a tissue-agnostic biomarker. A retrospective study in 228 Japanese patients with primary triple-negative breast cancer (TNBC) revealed a prevalence of 0.9% (two cases)26. ...
Radiotherapy is used to treat tumours, as it induces DNA damage in tumour cells[164], [165]. Radiotherapy provides a palliative strategy for the treatment of tumours. Radiotherapy is mainly used to treat tumours by inducing DNA damage in tumour cells[165], [166], [167]. Radiation therapy ...