Methods The female mice model with systemic lupus erythematosus was established by ip of nophytanes, and the model group, hydroxychloroquine (ig 80 mg/kg hydroxychloroquine) group, TLR9 inhibitor (ip 4 mg/kg ODN2088) group, hydroxychloroquine + ODN2088 group, and the normal control group was ...
This invention relates generally to the field of medicine, and particularly to a TLR-9-specific inhibitor peptide effective for modification of inflammatory signaling and host defense pathways. This peptide can be used for TLR-targeting pharmaceutics for treating inflammatory responses caused by various ...
ZY010Mu013蛋白Z依赖性蛋白酶抑制因子(ZPI)重组蛋白Recombinant Protein Z Dependent Protease Inhibitor (ZPI)Mus musculus (Mouse) ZY010Mu021结缔组织生长因子(CTGF)重组蛋白Recombinant Connective Tissue Growth Factor (CTGF)Mus musculus (Mouse) ZY010Mu022低密度脂蛋白受体相关蛋白1(LRP1)重组蛋白Recombinant Low...
ODN 4084-F is potent inhibitor of TLR9-induced B cells and macrophages [3]. References: 1. Lenert P. et al., 2003. Structural characterization of the inhibitory DNA motif for the type A (D)-CpG-induced cytokine secretion and NK-cell lytic activity in mouse spleen cells. DNA Cell ...
ODN INH-18 is a potent inhibitor of TLR9-induced B cells and macrophages [1]. ODN INH-18 strongly blocks TLR9 activation in both human and mouse TLR9-expressing cells. Reference: 1. Lenert P. et al., 2009. DNA-like class R inhibitory oligonucleotides (INH-ODNs) preferentially block ...
KL696Mu02 安定结合抑制因子(DBI)重组蛋白 Recombinant Diazepam Binding Inhibitor (DBI) Mus musculus (Mouse) KL706Ra01 蛋白信号调节因子6(RGS6)重组蛋白 Recombinant Regulator Of G Protein Signaling 6 (RGS6) Rattus norvegicus (Rat) 标题: 内容: ...
Thalidomide is known as a BBB-permeable inhibitor of TNF-α production25. To allow administered thalidomide enough time to be fully effective in inhibiting Tnf-α expression by the time of KA injection, we started the injection of thalidomide into WT mice 1 day before the KA injection, and co...
4c). Consistent with previous findings32, microglial depletion was similarly ineffective, as determined in both wild-type and Tlr9fl/fl mice receiving a CSF1R inhibitor in their diet or regular diet after injection of Syn-cre (Extended Data Fig. 4d,e). Introduction of Syn-cre in the ...
To investigate whether pDC activation was dependent on endosomal access and TLR9 binding, we pretreated pDCs with bafilomycin A1, an endosomal compartment acidificator or with ODN TTAGGG (A151), a TLR9 inhibitor. In both conditions, CXCL4–DNA complexes (Fig.5a) and LL37–DNA complexes22,25we...
we found that the TLR9 agonist CpG ODN(ODN 2006) can significantly increased the invasiveness of U87 glioma cells(Fig.4). Most importantly, we found that the CpG induced invasion could be blocked with chloroquine, which is an inhibitor of TLR9 signaling pathway. All the results suggested that...