TLR9-IN-1 英文名称: TLR9-IN-1 总访问: 39 国产/进口: 进口 半年访问: 13 产地/品牌: MedChemExpress(MCE) 产品类别: 生化试剂 规格: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg 最后更新: 2025-2-13 货号: HY-148045 CAS 号: 2226366-86-3 参考报价: 4173; 2045; 4500; 8000 立即询价 电话...
TLR9-IN-1 CAS No. : 2226366-86-3 MCE 站:TLR9-IN-1 产品活性:TLR9-IN-1 是一种有效且选择性的 TLR9 抑制剂,对人 TLR9 的 IC50 为7 nM。TLR9-IN-1可用于研究不良免疫应答相关疾病。 研究领域:Immunology/Inflammation 作用靶点:Toll-like Receptor (TLR) In Vitro: TLR9-IN-1 (compound no.29) ...
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TLR7 signaling was not able to compensate for the loss of TLR9 signaling in peritoneal B-1b cells to induce IgM Abs. Transfer of TLR9-expressing peritoneal B-1b cells from Fc纬RIIB-deficient mice or of recombinant monoclonal self-reactive IgM Abs was sufficient to reduce the frequency of ...
In summary, we find that transgene product-specific CD8+ T cell responses upon hepatic AAV gene transfer are mediated via IL-1R1-MyD88 signaling and are independent of TLR9. Immune pathways required for antibody formation to hepatic AAV vector Having defined that IL-1R1-MyD88 signaling was req...
Unlike their parental cells,THP1-Dual™, which weakly express TLR9, THP1-Dual™ hTLR9 cells are responsive to stimulation with TLR9 agonists, such as oligonucleotides containing CpG motifs (CpG ODNs). As expected, hTLR9 overexpression in THP1-Dual™ cells allows potent NF-κB and IRF re...
TLR9 regulates the assembly of the endolysosomal phosphatidylinositol 3-kinase complex (PI3KC3-C2)-which contains beclin1 and UVRAG-in skeletal muscle during exercise, and knockout of beclin1 or UVRAG inhibits the cellular AMPK activation induced by glucose starvation. Moreover, TLR9 functions in a...
Augmented TLR9-induced Btk activation in PIR-B-deficient B-1 cells provokes excessive autoantibody production and autoimmunity. J Exp Med. 2009;206(9):... T Kubo,Y Uchida,Y Watanabe,... 被引量: 128发表: 2009年 Augmented TLR9-induced Btk activation in PIR-B–deficient B-1 cells provokes...
After adjustment by age, sex, municipality, and genetic ancestry, genotype association analysis showed evidence of association with malaria susceptibility for variants in or near IL1B, TLR9, TREM1, IL10RA, and CD3G genes: rs1143629-IL1B (G/A-A/A, OR = 0.41, 95% CI = 0.21–0.78, P...
As the expression level of TLRs in a host is an indicator of its health status and its ability to defend the pathogen challenge, the aim of this study was to compare the tissue-specific expression profiles of TLR9 mRNA in Danio rerio (zebra fish) that were healthy and experimentally exposed...