品牌:Sigma-Aldrich 所属分类:生化标准品 货品编号: Sigma.P9582-5MG 品牌: Sigma 品名: Polyinosinic–polycytidylic acid potassium salt with buffer salts, TLR ligand tested 规格: 5MG 产品描述: Biochem/physiol Actions Transfection of Poly (I:C) into NIT-1 cells has been used as a model of...
Amongst all TLR ligands tested, Pam3CSK4 (TLR1/2-ligand) and poly(I:C)-(HMW) (TLR3/MDA5-ligand) were the best at reducing all HBV parameters. No or little viral rebound was observed after treatment arrest, implying a long-lasting effect on cccDNA. We also tested Riboxxol that ...
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InvivoGen offers a growing library of functionally tested synthetic TLR3 agonists: Poly(I:C) & Poly(A:U) - dsRNA analogs of different sizes in a free or labeled format NexaVant™ - a dsRNA of defined size with high molecular homogeneity Each ligand's specificity, activity, and potency...
While TLR7 dimerizes upon ligand binding, TLR8, which exists as an unliganded inactive dimer, performs structural reorganization after ligand recognition [4]. Once activated, TLR8 recruits the adaptor protein MyD88 to trigger IRF, AP-1, and NF-kB responses via TRAF6 (TNF receptor-associated ...
It has also been reported in in vitro inhibition of ligand binding. For optimal detection of TLR3 with this mAb by flow cytometry, PE-conjugated or Biotin-conjugated TLR3.7 (revealed with SAv-PE Product # 12-4312) are recommended.Applications Tested: This TLR3.7 antibody has been tested ...
Cutting Edge: FimH Adhesin of Type 1 Fimbriae Is a Novel TLR4 Ligand AutoimmunitySeveral TLR ligands of bacterial origin induce innate immune responses. Although FimH, the adhesin portion of type 1 fimbria, plays an important ... KL Mossman,MF Mian,NM Lauzon,... - 《Journal of Immunology》...
THP1-derived macrophages were stimulated by poly (I:C) (TLR3 ligand) or LPS (TLR4 ligand) with different doses or different times. As shown in Fig. 3a, TRIM14 protein was induced by poly (I:C) in THP1-derived macrophages in dose- and time-dependent man- ners. Similarly, LPS ...
Constitutive expression levels of bothtlr9and 21 transcripts were evident when analyzing the MACS- sorted IgM+B cells; hence, this was followed up by investigating if their ligand CpG would affect the expression pattern of selected immune genes. For all the assayed genes, the effect of non-CpG...
Ligand binding by TLR3 induces receptor dimerization which results in inducing NF-κB activation (via TRIF-linked RIP1/TLR3 interactions) and cytokine production. TLR3 has been shown to interact with a number of proteins including MYD88, TRAF6, TRIAD3, MAP3K7, and TAB2. Other Names: Toll ...