TCR Ligand Discovery via T-ScanT cell receptor (TCR) ligand discovery is crucial to monitoring Tcell responses to antigen and to identifying antigens reactive against orphan TCRs of interest. In a recent article, Elledge and colleagues describe a functional Tcell ligand screening platform for ...
predicting the probability of MHC molecules binding to peptides is a key step in current computational pipelines. Published MHC binding affinity prediction algorithm integrates ligand datasets into a machine
CD8+T cells provide antiviral immunity by eliminating virus-infected cells and establishing long-term immunological memory1,2,3,4. CD8+T cells recognize epitopes, peptides (p) bound to HLA class I (pHLA-I) on the surfaces of infected cells via TCRαβ. Memory CD8+T cells recognize conserv...
A*02–restricted HLA ligand, we immunopurified HLA complexes from 4 hematologic cancer cell lines (BV173, OCI-AML02, SUDHL6, and MAC2A) and 4 nonhematologic cancer cell lines (JMN, TPC-1, MDA-MB231, and PANC-1) and analyzed the immunopeptidome of the complexes via LC-MS/MS (Figure...