8. Dardalhon, Valerie et al. 「Tim-3/galectin-9 pathway: regulation of Th1 immunity through promotion of CD11b+Ly-6 G+ myeloid cells.」 Journal of immunology (Baltimore, Md. : 1950) vol. 185,3 (2010): 1383-92. 9. Koyama, Shohei...
产业前沿 | 肿瘤免疫治疗的赛道上 百奥赛图全面布局新型靶点TIM3 TIM3(T细胞免疫球蛋白及粘蛋白结构域分子3)又称HAVCR2,属于免疫调节蛋白TIM家族的一员,在人类,TIM家族包括TIM1、TIM3和TIM4,位于染色体5q33.2上。在小鼠中,TIM家族包括...
产品名称 TIM3/CD366 Rat mAb 别名 T淋巴细胞膜蛋白3(CD366)抗体 | TIM 3/CD366抗体 英文别名 Tim3 | TIM-3 | Timd3 | CD366 | FLJ14428 | HAVCR2 | HAVcr-2 | hepatitis A virus cellular receptor 2 | kidney injury molecule-3 | KIM-3 | SPTCL | T cell immunoglobulin mucin 3 | T...
Description: The RMT3-23 monoclonal antibody reacts with mouse CD366 (TIM3), a Th1-specific cell surface protein. The RMT3-23 antibody reacts with CD366 protein expressed by both BALB/c and C57BL/6 strains of mice. CD366, a type I transmembrane protein, contains an immunoglobulin and ...
在小鼠结直肠癌模型中,共同阻断 CD66a 和 TIM3 可增强抗肿瘤免疫应答,并消除肿瘤。 图2 TIM3介导的细胞免疫耐受 目前抗 PD-1 或抗 PD-L1 抗体与抗TIM3抗体联用是肿瘤免疫治疗的火热靶点。 蛋白表达分析 利用流式细胞术分析B-hPD-1/hPD-L1/hTIM3纯合小鼠中PD-1,PD-L1和TIM3表达。 取C57BL/6野生型...
Invitrogen Anti-CD366 (TIM3) Monoclonal (8B.2C12), eBioscience™, Catalog # 17-5871-82. Tested in Flow Cytometry (Flow) applications. This antibody reacts with Mouse samples. Supplied as 100 µg purified antibody (0.2 mg/mL).
TIM-3在小鼠结直肠癌模型中表现出增强抗肿瘤免疫应答并消除肿瘤的能力，尤其是在与CD66a共同阻断的情况下。当前，抗PD-1或抗PD-L1抗体与抗TIM3抗体的联用已经成为肿瘤免疫治疗的热门靶点。通过流式细胞术分析，可以评估B-hPD-1/hPD-L1/hTIM3纯合小鼠中PD-1、PD-L1和TIM3的表达情况。实验结果显示...
抗原:CD366 (TIM3)物种:人宿主:小鼠抗体亚型:IgG1, kappa克隆号:F38-2E2荧光染料:APC加入购物车 产品介绍 技术参数 相关产品 产品介绍 TIM3(甲型肝炎病毒细胞受体 2,HAVCR2,T 细胞免疫球蛋白)是一个 281 个氨基酸长,1 型 Th1 特异性细胞表面糖蛋白 ,表达于终末分化的 CD4+Th1 和 CD8+Tc1 细胞上。
Here, decreased CD8+T cells, less IFN-纬 secretion in CD8+T cells and increased TIM3 on CD8+T cells had been seen. Increased TIM3+CD8+T cells with lower perforin and granzyme B expression and higher CD95 expression in MDS patients had been observed. These findings suggested that TIM3 ...