3) thyroid hormone receptor β gene 甲状腺激素受体β基因 1. Thyroid hormone resistance with H435L mutation in exon 10 of thyroid hormone receptor β gene associated with Hashimoto's thyroiditis 甲状腺激素受体β基因第10外显子H435L突变致甲状腺激素抵抗并桥本甲状腺炎 更多例句>> 4) PTH/PTHrP ...
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Thyroid hormone(TH) is essential for the development and function of virtually all human tissues. Its importance is illustrated by the effects of hypo- andhyperthyroidism, which are among the most common diseases in the general population and have been associated with substantial morbidity, as well...
Thyroid-stimulating hormone and autoantibody M22 push the extracellular domain of the thyrotropin receptor into an upright active conformation, revealing a universal activation mechanism of glycoprotein hormone receptors and providing the molecular basis of Graves’ disease, hypothyroidism and Hashimoto’s dise...
A thyroid hormone receptor alpha gene mutation (P398H) is associated with visceral adiposity and impaired catecholamine-stimulated lipolysis in mice. J Biol Chem. 2003;278(40):38913–20. https://doi.org/10.1074/jbc.M306120200. Article CAS PubMed Google Scholar Pontikides N, Krassas GE. ...
33 '5-triiodothyronineAMP-activated protein kinaseCompound CThyroid hormone (T-3) induces liver preconditioning (PC) against ischemia-reperfusion (IR), a response energetically supported by AMP-activated protein kinase (AMPK) upregulation. The aim of this work is to evaluate the influence of T-3...
including those that maintain the protein structure and hormone synthesis45. A cDNA encoding wild-type mouse Tg (mTg-WT) expressed in 293T cells has normal synthesis and secretion of thyroid hormones46. We then introduced the observed humanTGvariants (rs116340633 and rs114322847) into the mTg ...
We constantly hear from our readers about some important questions. The first is about taking iodine while using other thyroid hormone-acting preparations. Is this safe and effective? The answer is always yes! Iodine is an essential mineral, necessary for the proper functioning of every cell in ...
1.1Thyroid-stimulating receptor (TSH-R) Thethyroid-stimulating hormonereceptor (TSH-R) belongs to the family of guanine-nucleotide binding (G) protein-coupled receptors (ANDO et al., 2005;DE LLOYD et al., 2010;PATIBANDLA and PRABHAKAR, 1996). It is encoded by the TSH-R gene located on ...
To identify the role of thyroid hormone receptor α (TRα) in the processes of β-cell growth and cell cycle regulation, we constructed a recombinant adenovirus vector, AdTRα. Infection with AdTRα to RIN5F cells increased the expression of cyclin D1 mRNA and protein. Overexpression of the...