(2001). Thyroid hormone response element sequence and the recruitment of retinoid X receptors for thyroid hormone responsiveness. J. Biol. Chem. 276:3929-3936.Wu Y, Xu B, Koenig RJ. Thyroid hormone response element sequence and the recruitment of retinoid X receptors for thyroid hormone ...
The thyroid hormone receptor is a member of the steroid/thyroid hormone receptor gene family (Fig. 16.17) and it binds to the hormone response element of double-stranded DNA (AGGTCATGACCT:TCCAGTACTGGA) as shown in Fig. 16.16 as a heterodimer with RXR. Note that there are no intervening ...
Thyroid hormone receptors are ligand-modulated transcription factors that can repress or activate transcription depending upon the absence or presence of thyroid hormone and the nature of the hormone response element to which the receptors are bound. The ability of thyroid hormone receptors to repress ...
To shed more light on the molecular requirements for recognition of thyroid response elements (TREs) by thyroid receptors (TRs), we compared the specific aspects of DNA TRE recognition by different TR constructs. Using fluorescence anisotropy, we performed a detailed and hierarchical study of TR-TRE...
3,5,3′-Triiodothyronine T4: Thyroxine TAAR1: Trace amine-associated receptor 1 TH: Thyroid hormone Tn: Troponin TR: Thyroid hormone receptor TRE: Thyroid hormone response element TSH: Thyroid-stimulating hormone VSMC: Vascular smooth muscle cell...
This nuclear T3-receptor complex binds to thyroid hormone response elements on specific genes and regulates their transcription (genomic pathway)10. In short, there are two isoforms of THRα (1 and 2). THRα1 can bind to T3 and subsequently promotes its effects, whereas THRα2 lacks this ...
Thyroid hormone stimulates renin gene expression through the thyroid hormone response element. Hyper- tension 37: 99 -104, 2001.Kobori H, Hayashi M, Saruta T 2001 Thyroid hormone stimulates renin gene expression through the thyroid hormone response element. Hypertension 37:99 -104...
Signal transducer and activator of transcription-3 TFEB: Transcription factor EB TH: Thyroid hormone THR: Thyroid hormone receptor TRAP: TR-associated protein TRE: Thyroid hormone response elements TRH: Thyrotropin-releasing hormone TSH: Thyroid stimulating hormone VDR: Vitamin D receptors...
However, mutation of TRE2 significantly reduced the response of the TRAIL promoter to T3. Regulation of TRAIL by thyroid hormone receptor H-C Chi et al Together, these data suggest that TRE2, located between positions –1967 and –1977, mediates the effect of T3 on the TRAIL promoter. ...
To identify the role of thyroid hormone receptor α (TRα) in the processes of β-cell growth and cell cycle regulation, we constructed a recombinant adenovirus vector, AdTRα. Infection with AdTRα to RIN5F cells increased the expression of cyclin D1 mRNA and protein. Overexpression of the...