Thyroid Hormone Receptor-beta Agonist GC-1 Inhibits Met-beta-Catenin-Driven Hepatocellular Cancer. Am J Pathol. 2017;187(11):2473-85.Puliga E, Min Q, Tao J, Zhang R, Pradhan-Sundd T, Poddar M, et al. Thyroid hormone receptor-β agonist GC-1 inhibits Met-β- catenin-driven ...
The results indicate that the TRbeta-selective agonist GC-1 is a strong mitogen for hepatocytes and pancreatic acinar cells. Furthermore, they suggest that the TRbeta receptor is the mediator for the mitogenic activity of thyroid hormone and other thyromimetics. 展开 ...
1.4Thyroid Hormone Receptors Thyroid hormone receptor(THR):There are two types ofTHR, alpha and beta (THRA and THRB), encoded by separate genes, and the proteins are highly conserved in vertebrates (Brent, 2012; Cheng et al., 2010). The humanTHRAgene has alternative splice products to yield...
The preovulatory surge of luteinizing hormone reaches a maximum at 18.00 h on the day of pro-oestrus in female rats maintained with regular lighting from 0... CW Coen,MC Coombs - 《Neuroscience》 被引量: 122发表: 1983年 Epiquinamide: a poison that wasn't from a frog that was. In 200...
Since systemic side effects of T3 may preclude its clinical use, and hepatocytes mostly express T3 hormone receptor beta (TRbeta), we investigated if selective TRbeta agonists like GC-1 may also have beta-catenin-dependent hepatocyte mitogenic effects. Here we studied the effect of GC-1 and ...
Resmetirom(MGL-3196) | Resmetirom (MGL-3196) is an orally active thyroid hormone receptor-beta (THR-beta) agonist with high specific uptake in liver. Selectivity for THR-beta may provide metabolic benefits of thyroid hormones in managing MASH. 链接 ...
Synthesis and preclinical testing of a selective beta-subtype agonist of thyroid hormone receptor ZTA-261 Article Open access 06 August 2024 References JF, C. Discovery of a new cure for goiter [De´- couverte d’un nouveau reme’de contre le goıˆtre]. Ann Chim Phys Paris 15, ...
Synthesis and preclinical testing of a selective beta-subtype agonist of thyroid hormone receptor ZTA-261 Article Open access 06 August 2024 References JF, C. Discovery of a new cure for goiter [De´- couverte d’un nouveau reme’de contre le goıˆtre]. Ann Chim Phys Paris 15, ...
1981. Thyroid hormone modulation of agonist ± beta-adrenergic receptor interactions in the rat heart. Life Sci 28, 2529±2536.Stiles GL and Lefkowitz RJ. Thyroid hormone modulation of agonist-beta-adrenergic receptor interactions in the rat heart. Life Sciences. 28(22):2529-36, 1981....
DiscoveryofaHighlySelectiveandH435R-SensitiveThyroidHormoneReceptorβAgonistQiuLi#BenqiangYao#ShitingZhaoZhouLuYanZhangQiupingXiangXishanWuHaonanYuChengZhangJunhuaLiXiaoxiZhuangDonghaiWuYongLi*andYongXu*CiteThis:J.Med.Chem.0657193−711ReadOnlineACCESSM