结果如下图所示。 3、对IFN-α诱导的外泌体和相应的THP-1-衍生巨噬细胞差异表达蛋白进行生物信息学分析。结果显示IFN‑α处理后巨噬细胞和外泌体中蛋白表达丰度均发生显著变化。IFN‑α处理后在巨噬细胞和外泌体中均增加了23个蛋白表达群的丰度,同时降低了1个蛋白质组的丰度。采用GO富集和KEGG对23种上调蛋...
2. Hesperetin upregulates the expression of LXRα protein and mRNA in THP-1-derived macrophages. 3. Hesperetin increases the expression of LXRα target proteins including ABCA1,ABCG1, and SR-BI. 4. AMPK is implicated in hesperetin-induced activation of LXRα signal and LXRα signal-mediated...
In the present study, we show that, the interaction between THP-1derived macrophage and OSCC cell line Cal-27 may up-regulate the Kif4A expression in both of them. Additionally, elevated soluble CCL2 in medium and more expression of CCR2 on macrophage were observed during the crosstalk. ...
THP-1-derived M0, M1 (IFN-纬 and LPS), and M2 (IL-4 and IL-13) macrophages were exposed (or not: control group) to 100 mV/mm of DC EStim, 1 h/day for three days. Macrophage polarization was assessed through gene and surface marker expressions and cytokine secretion profiles. ...
Since THP-1 cells lack the p53 gene [8], it is thought that the radioresistance of THP-1-derived macrophages is independent of the p53-mediated pathway. However, the mechanisms by which THP-1 cells acquire radioresistance during differentiation into macrophages remain unknown. We also demonstrated...
2 Methods and results We show that 6‐dihydroparadol concentration‐dependently enhances both apolipoprotein A1‐ and human plasma-mediated cholesterol efflux from cholesterol‐loaded THP‐1‐derived macrophages using macrophage cholesterol efflux assay. 6‐Dihydroparadol increases protein levels of both ...
Results suggest that the regulation of caspase-8-mediated apoptosis during differentiation plays a role in the p53-independent radioresistance of THP-1-derived macrophages. 展开 关键词: ionizing radiation, radioresistance, caspase-8, macrophages, apoptosis ...
Apoptosis of THP-1 derived macrophages induced by sonodynamic therapy using a new sonosensitizer hydroxyl acetylated curcumin. Apoptosis of THP-1derived macrophages induced by sonodynamic therapy using a new sonosensitizer hydroxyl acetylated curcumin. L.Zheng,X.Sun,X.Zhu,et al. ... Longbin,Zheng,...
Abstract: P720 DOWNREGULATION OF PCSK9 EXPRESSION SUPPRESSES THP-1 DERIVED MACROPHAGES APOPTOSIS INDUCED BY OX-LDLRARCH ModelQuai-Maximum LikelihoodExchange rates of RMBRCC modelThis paper presents a new extension of the multivariate ARCH model: RARCH model, which includes three forms: scalar,diagonal...
www.nature.com/scientificreports OPEN received: 16 April 2016 accepted: 16 January 2017 Published: 17 February 2017 Expression profiling of TRIM protein family in THP1-derived macrophages following TLR stimulation Mei-Xiu Jiang1, Xuan Hong1, Bin-Bin Liao1, Shui-Zhen Shi1, Xiao-Fang...