Thiazolidinediones (TZDs) or glitazones are agents that are widely used for the treatment of type 2 diabetes mellitus. These drugs have a multitude of therapeutic effects including reduction in insulin resistance and hyperglycaemia, anti-inflammatory effects and amelioration of hypertension, ...
Thiazolidinediones or glitazones specifically target insulin resistance. They have proven efficacy for reducing plasma glucose levels of type 2 diabetic patients treated with diet alone, sulphonylureas, metformin or insulin. In addition, they may be associated to some improvement of cardiovascular risk ...
We evaluated the effects of two thiazolidinediones (TZDs), the potent PPARgamma agonist rosiglitazone currently being used to treat diabetes, and a structurally similar experimental compound that is a poor PPARgamma agonist, in a non-dia... CW Bolten,MA Payne,WG Mcdonald,... - 《Diabetes & ...
6. TZDs have also been reported to have other serious adverse effects, such as cardiotoxicity, congestive heart failure, and even conceivable carcinogenesis in a few cases7,8. Hence, the pleiotropic effects of TZDs must
Exposure to TZD was defined as having filled a prescription for TZDs on two or more occasions during the baseline year. The majority of TZD patients in our study were prescribed rosiglitazone (96%), which was on the medication formulary at the VA during the study period; only 4% of TZD ...
Thiazolidinediones (TZDs) or glitazones are agents that are widely used for the treatment of type 2 diabetes mellitus. These drugs have a multitude of therapeutic effects including reduction in insulin resistance and hyperglycaemia, anti-inflammatory effects and amelioration of hypertension, ...
Thiazolidinediones (TZDs) or glitazones are agents that are widely used for the treatment of type 2 diabetes mellitus. These drugs have a multitude of therapeutic effects including reduction in insulin resistance and hyperglycaemia, anti-inflammatory effects and amelioration of hypertension, ...
Rosiglitazone and pioglitazone have been shown to be active as monotherapy, in combination therapy with metformin or sulfonylureas, and even in triple therapy. They are generally well tolerated but can induce fluid retention. Cardiac failure is a contraindication for the use of TZDs, as is the ...
The article examines the use of thiazolidinediones (TZDs) or glitazones for the treatment of diabetes. The way glitazones improve insulin action in muscle, adipose and hepatic tissue is cited. Significant advantages of glitazones over other commonly used glucose-lowering therapies are listed. ...
Thiazolidinediones (TZDs) or glitazones forms a significant class of drugs which exhibit an array of biological activities ranging from anti diabetic, anti-inflammatory, antibacterial, antifungal, antiviral and anticancer. 1, 3-Thiazolidine-2, 4-dione contains basic skeleton of thiazole or thiazolidine...