time-resolved femtosecond laser spectroscopyThe furore over Avandia ( rosiglitazone), GlaxoSmithKline's blockbuster drug for diabetes, illustrates how much the US drug business has changed over the past 3 years.doi:10.1038/nrd2363Sarah Crunkhorn SNature Reviews Drug Discovery...
摘要: The article presents information on thiazolidinediones, an antidiabetic drug used for the treatment of type 2 diabetes, including its dosage, usage, adverse reactions, side effects, precautions when administering, and possible interaction with other drugs. 展开 被引量: 1 年份: 2011 收藏...
Unfortunately, these drugs have discernible side effects at diabetic dose. However, rosiglitazone and pioglitazone are still in the market with controversies. Past few years have noted the use of these drugs for the treatment of various other ailments. AREAS COVERED: In this review, the authors ...
It remains unclear whether or not hepatotoxicity is a class effect or is related to the unique tocopherol side chain of troglitazone. Rosiglitazone and pioglitazone, two other glitazones, appear to have similar efficacy on blood glucose control of type 2 diabetic patients as compared to troglita...
King AB. A comparison in a clinical setting of the efficacy and the side effects of the three thiazolidinediones [letter]. Diabetes Care 2000; 23(4): 557 ArticlePubMedCASGoogle Scholar King AB, Armstrong D. Comparison of the glucose and lipid effects of rosiglitazone and pioglitazone following...
Metformin has a lower risk of side effects than phenformin and is widely prescribed for the treatment of Type 2 diabetes. -2- WO 2007/008501 PCT/US2006/026047 The glitazones (i.e. 5-benzylthiazolidine-2,4-diones) are a newer class of compounds that can ameliorate hyperglycemia and ...
Effectiveness and side effects of thiazolidinedi- ones for type 2 diabetes [Letter]. Med J Aust. 2005;182:492-3. [PMID: 15865597]Effectiveness and side effects of thiazolidinediones for type 2 diabetes. Arnold Nirusha,McLean Mark,Chipps David R,Cheung N Wah. The Medical journal of ...
Hussein Z,Wentworth J M,Nankervis A J, et al.Effectiveness and side effects of thiazolidinediones for type 2 diabetes: real-life experience from a tertiary hospital. Medical Journal of Australia . 2004Hussein Z,Wentworth J M,Nankervis A J, et al.Effectiveness and side effects of ...
In a second set of experiments, different concentrations of rosiglitazone and pioglitazone were administered in the presence or absence of the specific PPAR gamma antagonist GW9662, and their effects on the mitochondrial redox state were measured by online NADH and FAD autofluorescence. The ...
Using these rationalized approaches, several investigations have been carried out in recent years to develop newer TZDs devoid of side effects. This report critically reviews TZDs, their history, chemistry, mechanism mediated through PPAR, recent advances and future prospects....