time-resolved femtosecond laser spectroscopyThe furore over Avandia ( rosiglitazone), GlaxoSmithKline's blockbuster drug for diabetes, illustrates how much the US drug business has changed over the past 3 years.doi:10.1038/nrd2363Sarah Crunkhorn SNature Reviews Drug Discovery...
HOW ARE ANTIDIABETIC BIGUANIDES/THIAZOLIDINEDIONES USED? Glitazones are used as an adjunct to diet and exercise to improve glycemic control in adults with T2DM. WHAT ARE SIDE EFFECTS OF ANTIDIABETIC BIGUANIDES/THIAZOLIDINEDIONES? Some of the common side effects include: Diarrhea Nausea Vomiting Stoma...
摘要: The article presents information on thiazolidinediones, an antidiabetic drug used for the treatment of type 2 diabetes, including its dosage, usage, adverse reactions, side effects, precautions when administering, and possible interaction with other drugs. 被引量: 1 年份: 2011 收藏...
osteoporosisparathyroid hormone analogspelvistibiatrabecular bonevertebraeCompares the efficacy and side effects of thiazolidinediones (TZD). Effects on lipids; ... King,B A. - 《Diabetes Care》 被引量: 231发表: 2000年 Thiazolidinediones inhibit growth and invasiveness of the human adrenocortical cancer...
Recent research is beginning to clarify the mechanisms associated with these potential side effects and may result in the expanded use of this drug class in patients with heart failure. Because of the unique mechanism of action of this drug class that addresses a fundamental pathophysiolgical ...
A thiazolidine-2-4-dione structure is common to all agents of this class, but they differ in side-chain modifications which influence their pharmacologic actions and potential for adverse effects. Unlike the other thiazolidinediones, troglitazone was designed to contain an alpha-tocopherol moiety to...
Thiazolidinediones Abstract The thiazolidinediones troglitazone, rosiglitazone and pioglitazone reduce insulin resistance by altering gene expression involved in glucose and lipid metabolism, via binding to peroxisome proliferator-activated receptor γ. Thiazolidinediones show additive therapeutic effects when ...
Very recently, TZDs have been shown to reduce not only steatosis but possibly also hepatocellular damage in NASH.Given the uncertainties in benefits of TZDs in reducing cardiovascular disease in type 2 diabetes, as well as other side-effects (heart failure, fractures), TZDs may in the future ...
agonistic activity of5cand5d. The prototype of antihyperglycemic drugs is TZDs such as rosiglitazone and pioglitazone, which act as full agonists of the PPAR-γ receptor. However, they suffer from the disadvantages of causing heart failure, weight gain, edema, and obesity as side effects. PPAR-...
Although no serious side effects occurred in the pilot studies, we should look vigilantly for hepatotoxicity, as the first generation thiazolidinediones proved to be toxic for the liver. View Full Article (HTML) Get PDF (88K) More content like this Find more content: like this article Find...