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Brain PPAR-γ promotes obesity and is required for the insulin-sensitizing effect of thiazolidinediones. Nature Med. 17, 618–622 (2011). CAS PubMed Google Scholar Ryan, K. K. et al. A role for central nervous system PPAR-γ in the regulation of energy balance. Nature Med. 17, 623–...
The pathogenesis of COPD is closely related to the imbalance of protease/anti-protease, which leads to the destruction of the elastin framework.52Proteases are involved in tissue remodelling, inflammation and degradation of the extracellular matrix (ECM) components and the pathology of COPD.53,54In ...
39,40 As discussed earlier, the binding of ACE2 to spike glycoprotein of SARS-CoV-2 facilitates viral entry into the cells. Drugs that are used to treat diabetes including glucagon-like peptide-1 (GLP-1) agonists, thiazolidinediones, statins, ACEI, and ARB, are known to elevate ACE2 ...
(HbA1c 6.5C7.0%). With the exception of the glucagon-like peptide 1 analogs and the thiazolidinediones (2), additional antidiabetic medications shed their effectiveness to control hyperglycemia over time, partially due to the progressive decrease of -cell function (2C4). As a consequence, many ...
(HbA1c 6.5C7.0%). With the exception of the glucagon-like peptide 1 analogs and the thiazolidinediones (2), additional antidiabetic medications shed their effectiveness to control hyperglycemia over time, partially due to the progressive decrease of -cell function (2C4). As a consequence, many ...
[98] Thiazolidinediones Reduce TGF-b mRNA expression; inhibit TGF-b induced human type I procollagen promoter activity in human HSCs by interrupting the inhibition of [99,100] PPAR-g transcriptional activity 15-deoxy-delta12,14- prostaglandin J (2) These PPAR-g agonists markedly inhibit TGF-b1...
In clinical trials, liraglutide (in monotherapy or as add-on to 1 or 2 oral drugs) is as effective as, or more effective than, other agents (sulfonylureas, thiazolidinediones, dipeptidyl peptidase-4 inhibitors, insulin, and exenatide) in reducing hemoglobin A1c; induces weight ...
In this sense, the present article describes the mechanism of antiplatelet action of hypolipidemic (statins and fibrates), antidiabetic (thiazolidinediones) and antihypertensive (nifedipine) drugs via peroxisome proliferator-activated receptor (PPAR) activation. The mechanism of antiplatelet action of the ...
GLP-1RAs are recommended as second-line therapy in combination with metformin, sulfonylureas, thiazolidinediones or basal insulin, providing a means of enhancing glucose control while offsetting the weight gain associated with insulin and some oral agents. GLP-1RAs represent a useful tool that the ...