The Therapeutic Structural Antibody Database (Thera-SAbDab; http://opig.stats.ox.ac.uk/webapps/therasabdab) tracks all antibody- and nanobody-related therapeutics recognized by the World Health Organisation (WHO), and identifies any corresponding structures in the Structural Antibody Database (SAbDab...
The Therapeutic Structural Antibody Database (Thera-SabDab; http://opig.stats.ox.ac.uk/webapps/therasabdab) tracks all antibody- and nanobody-related therapeutics recognised by the World Health Organisation (WHO), and identifies any corresponding structures in the Structural Antibody Database (SAbDab...
DU, J. ET AL.: ' Structural basis for recognition of CD20 by therapeutic antibody Rituximab ' J. BIOL. CHEM. vol. 282, 2007, pages 15073 - 15080Du, J. et al., " Structural basis for recognition of CD20 by therapeutic antibody Rituximab "; J. Biol.Chem., May 18, 2007, vol. 282...
and during this time, antibody engineering has dramatically evolved. Current antibody drugs have increasingly fewer adverse effects due to their high specificity. As a result, therapeutic antibodies have become the predominant class of
Intranuclear proteins that package and order the DNA into structural units called nucleosomes. Glycocalyx A complex network of cell-bound proteoglycans, glycosaminoglycan side chains and sialoproteins that lines the luminal side of endothelial cells. Lymphocyte exhaustion A term that is used to indicate...
Insight into the structural determinants for selective inhibition of matrix metalloproteinases. Drug Discov. Today 12, 640–646 (2007). Article CAS PubMed Google Scholar Rao, B. G. Recent developments in the design of specific matrix metalloproteinase inhibitors aided by structural and computational ...
Pinto D et al (2020) Structural and functional analysis of a potent sarbecovirus neutralizing antibody. Nature 583:290–295 Article CAS PubMed Google Scholar Promislow DEL (2020) A geroscience perspective on COVID-19 mortality. J Gerontol A Biol Sci Med Sci 75:e30–e33 Article PubMed Pub...
Aside from proteins, exosomes can intrinsically act as an RNA shuttle service in the body for many coding or noncoding RNA species, including mRNAs, miRNA, Y RNA, transfer RNA fragment, vault RNA, structural RNA, repeat sequences, and RNA transcripts overlapping with protein coding regions[13,...
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A. Structural basis for hormone recognition by the Human CRFR2 G protein-coupled receptor. J. Biol. Chem. 285, 40351–40361 (2010). Article CAS PubMed PubMed Central Google Scholar Grace, C. R. et al. NMR structure and peptide hormone binding site of the first extracellular domain of ...