This class of G protein-coupled receptors (GPCRs) includes CXCR5, which is expressed predominantly on mature B cells and regulates their migration. CXCR5 has been implicated in numerous cancers, ranging from liquid cancers including Burkitt's lymphoma and chronic lymphocytic leukemia (CLL) to ...
Characterization of therapeutic antibodies and related products[J].Analytical Chemistry,2013,(02):715-736.Beck, A.; Wagner-Rousset, E.; Ayoub, D.; Van Dorsselaer, A.; Sanglier- Cianferani, S., Characterization of therapeutic antibodies and related products. Anal Chem 2013, 85 (2), 715-...
Therapeutic antibodies are widely used to treat severe diseases. Most of them alter immune cells and act within the immunological synapse; an essential cell-to-cell interaction to direct the humoral immune response. Although many antibody designs are generated and evaluated, a high-throughput tool fo...
P Rebello,G Hale - 《Journal of Immunological Methods》 被引量: 1540发表: 2002年 Strategies and challenges for the next generation of therapeutic antibodies Antibodies and related products are the fastest growing class of therapeutic agents. By analysing the regulatory approvals of IgG-based biothe...
Initial therapeutic strategies designed to target the NOTCH path... KG Geles,Y Gao,L Sridharan,... - 《Cancer Research》 被引量: 0发表: 2015年 NOVEL ANTI-NOTCH3 ANTIBODIES AND THEIR USE IN THE DETECTION AND DIAGNOSIS OF DISEASE The present invention relates to novel antibodies that bind ...
Human enterovirus 71 (EV71) has become the major pathogen of hand, foot and mouth disease (HFMD) worldwide, while the anti-EV71 antibody responses other than neutralizing epitopes have not been characterized. In this study, EV71 capsid proteins VP1, VP3,
Conclusions We characterized two mAbs neutralizing antibodies for HPV L1 protein, which would help develop genetic-engineered neutralizing antibodies against HPV16 for diagnostic and therapeutic purposes. 展开 关键词: Human papillomavirus Monoclonal antibody Variable regions ...
- 《Journal of Molecular Biology》 被引量: 101发表: 2009年 Antibodies in Single-Chain Format Against Tumour-Associated Antigens: Present and Future Applications. The recombinant antibodies in single-chain format (scFv) have found broad applications in both therapeutic and diagnostic fields. Tumour-...
22 Therefore, it is critical to define the RBD in SARS-CoV-2 S protein as the most likely target for the development of virus attachment inhibitors, neutralizing antibodies, and vaccines. In this study, we identified the RBD fragment in SARS-CoV-2 S protein and found that the recombinant ...
Potent prophylactic and therapeutic effects against SARS-CoV-2 are observed in rhesus monkeys. A single dose of MW05/LALA blocks infection of SARS-CoV-2 in prophylactic treatment and clears SARS-CoV-2 in three days in a therapeutic treatment setting. These results pave the way for the ...