This class of G protein-coupled receptors (GPCRs) includes CXCR5, which is expressed predominantly on mature B cells and regulates their migration. CXCR5 has been implicated in numerous cancers, ranging from liquid cancers including Burkitt's lymphoma and chronic lymphocytic leukemia (CLL) to ...
Sanglier-Cianferani, Characterization of therapeutic antibodies and related products, Anal. Chem. 15 (85) (2013) 715.Beck, A.; Wagner-Rousset, E.; Ayoub, D.; Van Dorsselaer, A.; Sanglier-Cianferani, S., Characterization of therapeutic antibodies and related products. Anal Chem 2013, 85...
P Rebello,G Hale - 《Journal of Immunological Methods》 被引量: 1540发表: 2002年 Strategies and challenges for the next generation of therapeutic antibodies Antibodies and related products are the fastest growing class of therapeutic agents. By analysing the regulatory approvals of IgG-based biothe...
Therapeutic antibodies are widely used to treat severe diseases. Most of them alter immune cells and act within the immunological synapse; an essential cell-to-cell interaction to direct the humoral immune response. Although many antibody designs are generated and evaluated, a high-throughput tool fo...
Sedimentation velocity analytical ultracentrifugation for characterization of therapeutic antibodies 来自 国家科技图书文献中心 喜欢 0 阅读量: 31 作者:S Uchiyama,M Noda,E Krayukhina 摘要: Sedimentation velocity analytical ultracentrifugation (SV-AUC) coupled with direct computational fitting of the observed ...
22 Therefore, it is critical to define the RBD in SARS-CoV-2 S protein as the most likely target for the development of virus attachment inhibitors, neutralizing antibodies, and vaccines. In this study, we identified the RBD fragment in SARS-CoV-2 S protein and found that the recombinant ...
Coxsackievirus A10(CVA10) recently emerged as a major pathogen of hand, foot, and mouth disease and herpangina in children worldwide, and lack of a vaccine or a cure against CVA10 infections has made therapeutic antibody identification a public health priority. By targeting a local isolate, CVA...
This is favorable since the mode of action of many brain therapeutic antibodies requires an extracellular target engagement (e.g., amyloid-β, α-synuclein, and tau aggregates), where uptake into neurons is unwarranted. The basigin receptor was first identified in mouse B16 melanoma cells and ...
Some of the disclosed antibodies bind Notch1 to the exclusion of other members of the Notch receptor family, while other antibodies bind Notch 1 and Notch3. Nucleic acid molecules encoding the Notch antibodies as well as methods of use thereof are also disclosed. Also included are pharmaceutical...
Potent prophylactic and therapeutic effects against SARS-CoV-2 are observed in rhesus monkeys. A single dose of MW05/LALA blocks infection of SARS-CoV-2 in prophylactic treatment and clears SARS-CoV-2 in three days in a therapeutic treatment setting. These results pave the way for the ...