Timeline from 1975 showing the successful development of therapeutic antibodies and their applications. Many biotech companies that promised antibodies as anticancer “magic bullets” were launched from 1981 to 1986. The height of the line and numerical annotations represent the estimated market value of ...
Development of therapeutic antibodies for the treatment of infection diseases and future aspect Since the late 1990s, therapeutic antibodies have been developed for various oncology and immunoinflammatory diseases. To date, more than 100 therapeutic a... K Haraya,K Gotanda,R Shiokawa,... - 《Drug...
a Therapeutic Monoclonal Antibody Product 55 Figure 5.1. Antibody Expression from Initial Production Cell Line Mini-Pools Generated with Selexis Genetic Element Vectors 108 Figure 5.2. Relative Expression Levels of Monoclonal Antibodies Obtained from ...
The purpose of therapeutic vaccines is to tar- get the existing antigens to maximize the induction of epitope-specific T cells that can reach the infection site and lesions to eliminate infection or B cells to pro- duce specific antibodies that can neutralize the virus [32]. The vaccine ...
The amyloid cascade hypothesis — which posits that the deposition of the amyloid-β peptide in the brain is a central event in Alzheimer's disease (AD) pathology — has strongly influenced recent AD drug discovery efforts. However, so far all agents tar
Therapeutic options in response to the COVID-19 outbreak are urgently needed. To facilitate the better and faster development of therapeutic COVID-19 drugs, we present an overview of the global promising therapeutic drugs, including repurposing existing antiviral agents, network-based pharmacology ...
Gene therapy represents the next step in the evolution of therapeutic development, which began with chemical compounds to treat symptoms (for example, aspirin to treat pain) and then advanced to biologic therapies (which could include proteins and antibodies) that modify disease (for example, enzyme...
The results from in vivo experiments showed that the levels of antibodies against the N and S proteins were higher than the levels of antibodies against M proteins in antisera from vaccinated mice, suggesting that epitope polypeptides from the N or S proteins may be potential targets for the ...
Wing Wai Yew& Chi Hung Chau 20Accesses 4Citations Explore all metrics Summary The global resurgence of tuberculosis and rampant drug resistance have rekindled the need for and interest in the development of new antitubercular drugs. Delineation of the possible drug targets furnished by the various...
However, advancements in our understanding of the amyloid cascade hypothesis have led to a development of disease-modifying therapeutic strategies. These include immunotherapies based on an infusion of monoclonal antibodies against amyloid-β, three of which have been approved for the treatment of ...