One of the main advantages of anti‐Xa relies on its hypothesized standardization, with a unique therapeutic range (0.30‐0.70 IU/ml) for all reagents, whereas APTT is influenced by numerous preanalytical and analytical parameters not related to the anticoagulant activity of UFH. Methods The aim ...
The American College of Chest Physicians (ACCP) recommends that the activated partial thromboplastin time (aPTT) therapeutic range for unfractionated heparin be defined as the aPTT corresponding to a heparin concentration of 0.3-0.7 micro/mL by heparin anti-factor Xa assay. This recommendation suggests...
The UFH therapeutic range was determined using 3 previously described methods: calibration of the aPTT to 0.3 to 0.7 U/mL anti-Xa activity, application of 1.5 to 2.5 times the control aPTT, or using 0.3 to 0.7 U/mL anti-Xa activity directly. We also applied the UFH therapeutic range of ...
241 RISK OF SUPRATHERAPEUTIC APTT IN THE ABSENCE OF AN INITIAL UNFRACTIONATED HEPARIN BOLUS F Bonenfant, B Cossette, V Nault, M Turgeon, M Paulin, D Echenberg, P Charron, M Lépine, T Fayad, P Farand Sherbrooke, Québec BACKGROUND: Unfractionated heparin (UFH) is an anticoag- ulant ...
viral infection in hepatocytes or cholangiocytes and drug-induced liver injury. The cytokine storm may initiate a violent attack to the host and result in liver injury. Dramatical increase in a wide range of proinflammatory cytokines and chemokines such as GM-CSF and IL-6 was observed in pati...
We recommend a target value of < 1.5 for INR. The INR was developed to help ensure that VKAs are administered at doses within the therapeutic range [38]. The higher the INR value, the higher the bleeding risk. In patients with TBI and an INR > 2, the odds ratio for ICH has ...
therapeutic rangeactivated partial thromboplastin timeAPTTanti-FXa assayIntroduction: Heparin is one of the oldest biological medicines with an established role in prevention and treatment of arterial and venous thromboembolism. Published therapeutic ranges for unfractionated heparin (UFH) mostly precede the ...
APTT therapeutic range for monitoring unfractionated heparin therapy. Significant impact of the anti-Xa reagent used for correlation: COMMENTdoi:10.1111/jth.15356Michael J. KovacsDepartment of Medicine Western University London ON CanadaAlejandro Lazo-Langner...
C0591: Establishing APTT Therapeutic Range for Patients Receiving Standard Unfractioned HeparinThe efficiency of human recombinant erythropoietin in alleviating anaemia in haemodialyzed patients has been well documented. However, the effects of rHuEPO therapy in correction of antioxidant capacity are not ...
The recommendation was to adjust the dose of unfractionated heparin in order to prolong the activated partial thromboplastin time (aPTT) to a range that corresponds to a heparin level of 0.2 to 0.4 U/mL by protamine titration or 0.3 to 0.6 or 0.7 U/mL by heparin anti-factor Xa analysis....