Plasma from normal volunteers and patients on stable warfarin therapy was heparinised in vitro and the APTT measured using a range of calcium chloride concentrations. A striking difference was noted between the reagent systems using kaolin as an activator compared with those using ellagic acid. With...
Levels of Coagulation Factors and detection of FV inhibitor (64 BU) Lab test Patient's result Normal range PT 56 11-14 sec PT% 13% 90-110% INR 6.55 0.8-1.2 APTT 181 29-40 sec Fibrinogen 289 180-400 mg/dL D-Dimers 890 0-500 [micro]gr/Lt FVIII 1% 65-150 FIX 8% 65-150 FII ...
This E1 was defined as 1.5-2.5 times the mean normal aPTT. A second empiric therapeutic range (E2) was defined as 1.5-2.5 times the patient's baseline aPTT. The aPTT HCDTR had been defined in a previous study as 48-61 seconds. In phase 2, heparin dosage adjustment decisions guided by...
Samples with prolonged APTT as compared to the in-range anti-Xa were allocated in 4 groups based on fibrinogen (<1.5g/dL or ≥ 1.5g/dL) and INR (<1.5 or ≥1.5) on the same day as the sample with prolonged APTT. Mortality of patients with normal fibrinogen ànd INR was then compared...
The mean +/- 2 SD of the LR of the 99 healthy volunteers was used as reference range (LR: 0.95-1.07). All patients treated either with heparin or oral anticoagulants remained negative in the MLXCON-LA assay (specificity, 100%), while one of five patients with hemophilia A, in whom a...