A therapeutic serum level of phenytoin (PHT) is difficult to achieve in patients who receive enteral tube feeding. In four patients, PHT capsules were dissolved in 250 ml warm water and cooled to body temperature before being administered. A therapeutic serum level of PHT was maintained in all...
A therapeutic serum level of phenytoin (PHT) is difficult to achieve in patients who receive enteral tube feeding. In four patients, PHT capsules were dissolved in 250 ml warm water and cooled to body temperature before being administered. A therapeutic serum level of PHT was maintained in all...
In order to explore the therapeutic potential of Nav1.5 expression in BCa, we next tested the effect of a widely used VGSC-blocking anticonvulsant drug, phenytoin (50 μM), on Na+current in BCa cells, using whole-cell patch clamp recording. This concentration is within the serum therapeutic ...
Pharmacogenetics: the therapeutic drug monitoring of the future? Genetic variability in drug response occurs as a result of molecular alterations at the level of drug-metabolising enzymes, drug targets/receptors, and dru... MHH Ensom,TKH Chang,P Patel - 《Clinical Pharmacokinetics》 被引量: 182...
There are few studies that have carefully studied the therapeutic concentration range of Phenytoin as an antiarrhythmic agent. Within this context, the therapeutic concentration range appears to be from 10 to 20μg/ml; from the neurology literature toxicity occurs when concentrations exceed 20μg/ml...
Changes in Serum Level of Four Antiepileptics in Okayama University Hospital over 14 Years Changes in the serum level of four antiepileptics (phenytoin, phenobarbital, carbamazepine, and valproic acid), which were measured by Okayama University M... S Yamashita,M Moriyama,K Furuno,... - 《Japan...
The pain most often occurs in the hands and feet and has been described as agonizing, burning, tingling, and lancinating.76 Neuropathic pain due to Fabry dis- ease is often managed with anticonvulsant drugs (e.g., carbam- azepine or phenytoin),77 because conventional analgesics and narcotic ...
Therapeutic drug monitoring is now widely used in many areas of medicine. With its proliferation has come an understanding of the clinical situations in wh
ChemicalChemicalChemicalPIP Level category(common name)(IUPAC nomenclature)(% control)SD valproic acid (VPA)2-propylpentanoic acid32.08.7 Shorter than 5 carbons backbone (the longest aliphatic side chain) acids 5 carbon backbone acids 6 Carbon backbone acids ...
On the whole, anticonvulsant treatment using phenytoin for patients suffering from dialysis encephalopathy is difficult. The dosage has to be adjusted according to the patient's individual plasma level, which has to be monitored closely. The cause might be altered protein binding of phenytoin due to...